Charles Rosenfeld, MD

Professor
Endowed Title: George L. MacGregor Professorship in Pediatrics
Pediatrics, Anesthesiology & Pain Management, Obstetrics & Gynecology
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

charles.rosenfeld@utsouthwestern.edu

To make an appointment, call 214-730-KIDS (5437).

Biography

Dr. Rosenfeld attended college at Emory University and graduated from Emory University School of Medicine. He completed his general training in Pediatrics at Yale-New Haven Medical Center and Albert Einstein College of Medicine, where he also was Chief Resident. He then spent a year as a Pediatric Pulmonary Fellow with Amile Scarpelli, MD, PhD at Albert Einstein, followed by 2 yrs in the Perinatal Research Program at the University of Colorado Health Sciences Center under the mentoring of Frederick Battaglia, MD and Giacomo Meschia, MD. After joining the faculty at UT Southwestern in 1973, Dr. Rosenfeld established a perinatal biology laboratory for the study of cardiovascular changes in pregnancy, and in particular, the study of uteroplacental and umbilicoplacental blood flows. He has received nearly continuous funding from NIH for his studies of the mother and fetus for 32 yrs, as well as other grants, making contributions to our understanding of cardiovascular changes in pregnancy and during fetal and neonatal development. He was the Director of the Division of Neonatal-Perinatal Medicine for nearly 35 yrs and has provided research training and mentoring for more than 15 fellows in his specialty, 5 in Maternal-Fetal Medicine, and numerous postdoctoral and medical students. His publication record exceeds 150 peer-reviewed articles and chapters in several textbooks. Dr Rosenfeld was the 2005 recipient of the Founders Award given by the Southern Society for Pediatric Research for his research contributions to child health and was elected a Fellow in the Section of Heart and Circulatory Physiology, American Physiological Society in 2005.

Education

FellowshipUniversity of Colorado Health Sciences Center (1973)
FellowshipBronx Municipal Hospital Ctr. (1971)
ResidencyAlbert Einstein Medical Center (1970)
ResidencyAlbert Einstein Medical Center (1969)
InternshipYale-New Haven Hospital (1967)
Medical SchoolEmory University School of Medicine (1966)

Research Interests

Blood pressure regulation before and after birth
Cardiovascular role of estrogen in pregnancy
Development of the renin-angiotensin system
Mechanisms modulating uteroplacental blood flow

Publications

Featured
Pregnancy modifies the large conductance Ca2+-activated K+ channel expression and cGMP-dependent signaling pathway in uterine vascular smooth muscle

Rosenfeld CR, , Liu X-t, and DeSpain K , Am J Physiol: Heart Circ Physiol , June 2009; (In press)

Featured
Ca2+ -activated K+channels modulate basal and E2 -induced rises in uterine blood flow in ovine pregnancy.

Rosenfeld CR, Cornfield DN, and Roy T , Am J Physiol: Heart Circ Physiol , 2001; (281):H22-H31

Featured
Ontogeny of vascular angiotensin II receptor subtype expressin in ovine development.

Cox BE and Rosenfeld CR , Pediatr Res , 1999; (45):414-424

Featured
Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep.

Naden RP and Rosenfeld CR , J Clin Invest , 1981; (68):468-474

Featured
Circulatory changes in the reproductive tissues of ewes during pregnancy.

Rosenfeld CR, Morris FH, Jr., Makowski EL, Meschia G, and Battaglia FC. , Gynecol Invest , 1974; (5):252-268

Large conductance Ca+2-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries.

Rosenfeld CR, Word RA, DeSpain K, Liu X-t. , Reprod Sciences , 2008; (15):651-660

The renin-angiotensin system in conscious newborn sheep: metabolic clearance rate and activity.

Velaphi SC, DeSpain K, Roy T, and Rosenfeld CR , Pediatr Res , 2007; (61):681-686

Vascular development beginning in early ovine gestation: carotid smooth muscle function, phenotype and biochemical markers.

Hutuna, C, Cox BE, Liu X-t, DeSpain, K and Rosenfeld CR , Am J Physiol: Regulatory Integrative Comp Physiol , 2007; (293):323-333

Vessel-specific regulation of angiotensin II receptor subtypes during ovine development.

Cox BE, Liu X, Fluharty, SJ, Rosenfeld CR , Pediatr Res , 2005; (57):124-132

Large-conductance Ca2+-dependent K+ channels regulate basal uteroplacental blood flow in ovine pregnancy.

Rosenfeld CR, Roy T, DeSpain, K, Cox, BE. , J Soc Gynecol Investig , 2005; (12):402-408

Honors/Awards

SSPR Founders Award

Recognition for research contributing to improving child health, Southern Society of Pediatric Research (2005)

Associate Editor, Reproductive Sciences (JSGI)

Appointed to the initial Editorial Board; evaluating basic research (1993)

George L. Mac Gregor Professorship of Pediatrics - 1993-Present

Recognition for research contributions in Perinatal Medicine (1993)

Associate Editor, Early Human Development

Responsible for all manuscripts in the Americas (1986)

Perinatal Research Society

Recognition for contributions to studies in pregnancy and development (1981)

Professional Associations/Affiliations

American Academy of Pediatrics

American Pediatric Society

American Physiologic Society

Society for Gynecologic Investigation

Society for Pediatric Research