Carla Green, PhD

Professor
Endowed Title: Distinguished Scholar in Neuroscience 2010-2014
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1800
Office Fax: 214-648-1801

carla.green@utsouthwestern.edu

Biography

1986-1991 Graduate Student with Dr. Simon Kwok, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center

1991-1996 Postdoctoral Fellow with Dr. Joseph Besharse, Department of Anatomy & Cell Biology, University of Kansas Medical Center

1996-1997 Research Assistant Professor, Department of Anatomy & Cell Biology, University of Kansas Medical Center

1997-2003 Assistant Professor, Department of Biology, University of Virginia

2003-2007 Associate Professor, Department of Biology, University of Virginia

2007-2009 Professor, Department of Biology, University of Virginia

2009-present Professor, Department of Neuroscience, UT Southwestern

Education

Graduate SchoolUniversity of Kansas Medical Center, Biochemistry (1991)
Graduate SchoolSouthwest Missouri State University, Biology (1986)
UndergraduateSouthwest Missouri State University, Biology (1984)

Research Interests

Circadian control of metabolism
Molecular mechanisms of circadian rhythmicity
Post-transcriptional regulatory mechanisms

Publications

Featured
Nuclear localization and transcriptional repression are confined to separable domains in the circadian protein CRYPTOCHROME

Zhu, H., Conte, F. and Green, C.B. , Current Biology , 2003; (13):1653-1658

Featured
Nocturnin, a deadenylase in Xenopus laevis retina: a mechanism for posttranscriptional control of circadian-related mRNA

Baggs, J. and Green, C.B. , Current Biology , 2003; (13):189-198

Featured
) In vivo disruption of Xenopus CLOCK in the retinal photoreceptor cells abolishes circadian melatonin rhythmicity without affecting its production levels

Hayasaka, N., LaRue, S., and Green, C.B. , Journal of Neuroscience , 2002; (22):1600-1607

Featured
Both Xenopus CRY1 and CRY2 functions require an intact flavin-binding domain, but are differentially sensitive to mutations in a putative flavin electron transport pathway.

Zhu, H. and Green, C.B. , Current Biology , 2001; (11):1945-1949

Featured
Identification of a novel vertebrate circadian clock regulated gene encoding the protein nocturnin

Green, C.B. and Besharse, J.C. , Proceedings of the National Academy of Sciences, U.S.A. , 1996; (93):14884-14888

Generation of a novel allelic series of cryptochrome mutants via mutagenesis reveals residues involved in protein:protein interaction and CRY2-specific repression.

McCarthy, E.v., Baggs, J.E., Geskes, J.M., Hogenesch, J.B. and Green, C.B. , Molecular Cellular Biology , 2009; (29):5465-5476

The meter of metabolism

Green, C.B., Takahashi, J.S. and Bass, J , Cell , 2008; (134):2-16

Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli

Garbarino-Pico, E., Rollag, M.D., Strayer, C.A., Niu, S., Besharse, J.C., and Green, C.B. , RNA , 2007; (13):745-755

Structure/function analysis of Xenopus CRYPTOCHROME 1 and 2 reveals differential nuclear localization mechanisms and functional domains important for interaction with and repression of CLOCK:BMAL1

van der Schalie, E.A., Conte, F.E., Marz, K.E. and Green, C.B. , Molecular Cellular Biology , 2007; (27):2120-2129

Loss of nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity

Green, C.B.*, Douris, N.*, Kojima, S., Strayer, C.A., Fogerty, J., Lourim, D., Keller, S. and Besharse, J.C. , Proceedings of the National Academy of Sciences, U.S.A. , 2007; (104):9888-9893

Honors/Awards

Fellow, American Association for the Advancement of Science

(2005)

The Karl Kirchgessner Foundation Research Award

(1998)

C.J. Herrick Award

Presented by The Anatomy Society for ?Outstanding Young Investigator in Comparative Neurology (1990)

Professional Associations/Affiliations

Society for Neuroscience

Society for Research on Biological Rhythms