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Metabolic imaging using MR

MRI/MRS provide useful information of in vivo metabolism and tissue heterogeneity ranging from anatomical change to cellular metabolism.

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Metabolic changes after cancer therapy

Hyperpolarized [1-13C]pyruvate can detect acute anti-VEGF treatment responses in glioma.

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Branched-chain amino acids metabolism

Altered BCAA metabolism in glioma can be measured using hyperpolarized α-ketoisocaproic acid.

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Cerebral TCA cycle activity

[2-13C]pyruvate allows in vivo assessment of mitochondrial metabolism.

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Clinical translation

Multiple in-human studies are in progress in the lab.