Featured Publications

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Zhang Z, Gallagher T, Scherer PE, Beutler B, Proc. Natl. Acad. Sci. U.S.A. 2020 May 117 21 11829-11835

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B Proc. Natl. Acad. Sci. U.S.A. 2016 Oct 113 42 E6418-E6426

The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-?B Signaling via Partial Degradation of the NF-?B Subunit p100.

Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z J. Biol. Chem. 2015 Jun

Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.

Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, Liu F, Zhang L, Zhao Y, J. Cell Biol. 2013 Nov 203 4 575-83

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D PLoS Biol. 2013 Nov 11 11 e1001721

Hedgehog in the Drosophila testis niche: what does it do there?

Zhang Z, Pan C, Zhao Y, Protein Cell 2013 Sep 4 9 650-5

Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

Zhang Z, Lv X, Yin WC, Zhang X, Feng J, Wu W, Hui CC, Zhang L, Zhao Y Dev. Cell 2013 Jun 25 6 636-44

Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis.

Zhang Z, Lv X, Jiang J, Zhang L, Zhao Y Cell Res. 2013 Feb

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.

Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B, J. Exp. Med. 2020 Apr 217 4

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.

Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B, Proc. Natl. Acad. Sci. U.S.A. 2019 May