Featured Publications

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm.

Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS Cell 2013 Feb 152 5 1091-105

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.

Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS Elife 2013 2 e00426

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.

Koike, N., S.H. Yoo, H.C. Huang, V. Kumar, C. Lee, T.K. Kim and J.S. Takahashi. Science August 2012

Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.

Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H, Takahashi JS   Science 2012 Jul 337 6091 189-94

Temperature as a universal resetting cue for mammalian circadian oscillators.  

Buhr ED, Yoo SH, Takahashi JS   Science 2010 Oct 330 6002 379-85

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.

Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB Proc. Natl. Acad. Sci. U.S.A. 2015 Dec

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale.

Wang GZ, Hickey SL, Shi L, Huang HC, Nakashe P, Koike N, Tu BP, Takahashi JS, Konopka G Cell Rep 2015 Dec 13 9 1868-80

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.

Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M Neuron 2015 Mar 85 5 1086-102

Vasoactive Intestinal Polypeptide (VIP)-Expressing Neurons in the Suprachiasmatic Nucleus Provide Sparse GABAergic Outputs to Local Neurons with Circadian Regulation Occurring Distal to the Opening of Postsynaptic GABAA Ionotropic Receptors.

Fan J, Zeng H, Olson DP, Huber KM, Gibson JR, Takahashi JS J. Neurosci. 2015 Feb 35 5 1905-20

A tunable artificial circadian clock in clock-defective mice.

D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C Nat Commun 2015 6 8587