Publications for Sarah Sinnett, Ph.D.

Sinnett SE, Boyle E, Lyons C, Gray SJ. Engineered microRNA-based regulatory element permits safe high-dose miniMECP2 gene therapy in Rett mice. Brain 2021 May 5 ():. PMID:33950254

Ozlu C, Bailey RM, Sinnett SE, Goodspeed KD. Gene Transfer Therapy for Neurodevelopmental Disorders. Dev Neurosci 2021 Apr 21 ():1/11/2021. PMID:33882495

Casy W, Ling Q, Shaffo FC, Sinnett SE, Gray SJ. AAV-Mediated Gene Therapy in CNS Genetic Disorders. Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease, Sixth Edition. 2020.

Fagiolini M, Patrizi A, LeBlanc J, Jin LW, Maezawa I, Sinnett SE, Gray SJ, Molholm S, Foxe JJ, Johnston MV, Naidu S, Blue M, Hossain A, Kadam S, Zhao X, Chang Q, Zhou Z, Zoghbi H. Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders. Neuroscience 2020 Oct 1 445():190-206. PMID:32360592

Sinnett SE, Gray SJ. Recent endeavors in MECP2 gene transfer for gene therapy of Rett syndrome. Discov Med 2017 Oct 24(132):153-159. PMID:29272692

Gadalla KKE, Vudhironarit T, Hector RD, Sinnett SE, Bahey NG, Bailey MES, Gray SJ, Cobb SR. Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome. Mol Ther Methods Clin Dev 2017 Jun 16 5():180-190. PMID:28497075

Sinnett SE, Brenman JE. The Role of AMPK in Drosophila melanogaster. Exp Suppl 2016 107():389-401. PMID:27812989

Sinnett SE, Hector RD, Gadalla KKE, Heindel C, Chen D, Zaric V, Bailey MES, Cobb SR, Gray SJ. Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery. Mol Ther Methods Clin Dev 2017 Jun 16 5():106-115. PMID:28497072

Sinnett SE, Brenman JE. Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators. Pharmacol Ther 2014 Jul 143(1):111-8. PMID:24583089

Sinnett SE, Sexton JZ, Brenman JE. A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK). Curr Chem Genom Transl Med 2013 7():30-8. PMID:24396733

Knapp DJ, Overstreet DH, Huang M, Wills TA, Whitman BA, Angel RA, Sinnett SE, Breese GR. Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats. Psychopharmacology (Berl) 2011 Nov 218(1):179-89. PMID:21643675