Life, as we know it, is a dynamic network of metabolic reactions that take nutrients from the environment and convert them into the building blocks and energy that cells need to grow and function. Each cell has a unique set of biosynthetic and energetic demands that must be met to ensure normal homeostasis. As a result, cells must establish distinct metabolic states to meet those demands. Disruption of these mechanisms can lead to severe developmental disorders and promote the progression of diseases such as cancer, neurodegeneration, and reproductive disorders.
Our primary goal in the lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression. Using a combination of genetics, molecular biology, and system based approaches (metabolomics, proteomics, and transcriptomics) we are investigating metabolic mechanisms that support reproduction and development in Drosophila and mammalian tissues. Our work focuses on three key areas:
- Understanding the role of metabolism in cellular quiescence.
- Examining how mitochondrial metabolism impacts growth and differentiation.
- Investigating how cellular metabolism regulates developmental signaling pathways.
Rotation projects for 2021:
- Conducting metabolomic analysis to understand how metabolic reprogramming impacts redox balance in response to maternal metabolic stress.
- Determining how mitochondrial metabolism regulates differentiation by controlling receptor trafficking.
- Investigating how fatty acid oxidation regulates proteasome function and cytosolic proteostasis.