Featured Publications

New insights into melanoma development.

Shay JW Science 2017 Sep 357 6358 1358-1359

A Method for Measuring the Distribution of the Shortest Telomeres in Cells and Tissues

Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW Nature Communications 2017 8 1

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer.

Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW PLoS Biol. 2016 Dec 14 12 e2000016

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.

Min J, Shay JW Cancer Discov 2016 Nov 6 11 1212-1214

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW Sci Transl Med 2016 Oct 8 361 361ra140

Role of Telomeres and Telomerase in Aging and Cancer.

Shay JW Cancer Discov 2016 Mar

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.

Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW Cancer Discov 2015 Jan 5 1 82-95

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE Genes Dev. 2014 Nov 28 22 2464-76

Alternative splicing regulation of telomerase: a new paradigm?

Wong MS, Wright WE, Shay JW Trends Genet. 2014 Aug

Specific association of human telomerase activity with immortal cells and cancer.

Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW Science 1994 Dec 266 5193 2011-5