Other Research


We have identified a factor involved in initial binding of host cells by a wide range of Gram-negative pathogens, Multivalent Adhesion Molecule (MAM) 7. Interference with MAM7-mediated attachment, by pre-incubation of host cells with recombinant MAM7, significantly delays the onset of hallmarks of infection. Targeting or exploiting MAM7 might provide a valuable tool for combating Gram-negative bacterial infections and we are currently exploring applications of MAM7 as an antimicrobial agent.