My research is focused on determining how PARP-1 activity on chromatin affects the transcription of the genes. In particular, I’m interested in how ADP-ribosylation from PARP-1 may be regulating the activity of enhancers. Towards this end, I’m currently utilizing the Kraus Lab analog sensitive PARP tools to identify which regions of chromosomes are modified by ADP-ribosylation.
Maeshima, K., Rogge, R., Tamura, S., Joti, Y., Hikima, T., Szerlong, H., . . . Hansen, J. C. (2016). Nucleosomal arrays self-assemble into supramolecular globular structures lacking 30-nm fibers. Embo j, 35(10), 1115-1132. doi:10.15252/embj.201592660