We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. We utilize light microscopy, particularly single-molecule and super-resolution imaging, to monitor molecular behavior in its native cellular environment, and we develop computer vision and mathematical modeling approaches to quantitate the observed behavior and gain insight beyond what the eye can see.
We hope that you enjoy the following 2-min Science Sketch video about the lab ...
... and our recent publications:
Vega A., Freeman S. A., Grinstein S., Jaqaman K. (2018). Multi-step track segmentation and motion classification for transient mobility analysis. Biophys. J. 114: 1018 – 1025.
Freeman S. A., Vega A., Riedl M., Collins R. F., Ostrowski P. P., Woods E. C., Bertozzi C. R., Tammi M. I., Lidke D. S., Johnson P., Mayor S., Jaqaman K., Grinstein S. (2018). Transmembrane pickets connect cyto- and pericellular-skeletons forming barriers to receptor engagement. Cell 172: 305 – 317.