We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. We utilize light microscopy, particularly single-molecule and super-resolution imaging, to monitor molecular behavior in its native cellular environment, and we develop computer vision and mathematical modeling approaches to quantitate the observed behavior and gain insight beyond what the eye can see.
We hope that you enjoy the following 2-min Science Sketch video about the lab ...
... and our recent publications:
Da Rocha-Azevedo B., Lee S., Dasgupta A., Vega A. R., do Oliveira L. R., Kim T., Kittisopikul M., Malik Z. and Jaqaman K., 2020. Heterogeneity in VEGF Receptor-2 mobility and organization on the endothelial cell surface leads to diverse models of activation by VEGF. Cell Reports. 32: 108187.
Kittisopikul M., Vahabikashi A., Shimi T., Goldman R. D. and Jaqaman K., 2020. Adaptive multi-orientation resolution analysis of complex filamentous network images. Bioinformatics, Online ahead of print.
De Oliveira L. R. and Jaqaman K., 2019. FISIK: Framework for the Inference of in Situ Interaction Kinetics from single-molecule imaging data. Biophysical Journal. 117: 1012-1028.