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Welcome!
Welcome to the Harris-Tryon Laboratory in the Department of Dermatology and Immunology
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Innate Immunity
Our main mission is to understand mechanisms that the skin uses to protect the host from infection. We seek to translate our discoveries into new therapies for individuals with skin diseases such as atopic dermatitis, hidradenitis suppurativa, and acne.
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Sebaceous Glands
In addition to producing sebum, sebaceous glands generate antimicrobial proteins that limit colonization of the skin by bacteria. Bacteria can also utilize sebocyte products as a nutrient. Thus, changes in sebaceous gland biology might drive changes in the microbiome.
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Diet and Skin Immunity
Our laboratory is also broadly interested in how the diet modifies skin immunity. We have shown that modulation of vitamin A has effects on the expression of an antimicrobial protein in skin. Our group continues to explore how changes in the host diet can modulate skin immunity.
Meet the PI
Dr. Harris-Tryon received her Ph.D. degree in Cellular and Molecular Medicine and a medical degree (M.D.) from the Johns Hopkins School of Medicine Medical Scientist Training Program.
Research
Skin is the largest organ in the body and harbors bacteria, fungi, viruses, and parasites on the surface and within skin appendages. Using a range of experimental approaches, we investigate the interactions between skin bacteria and the immune system.
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About Us
Welcome to the Harris-Tryon lab home page. Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.
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