Lab Focus

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery. We use an approach that brings together the strengths of X-ray crystallography, advanced mass spectrometry, cryo-electron microscopy and computer modeling to unravel the molecular details of these complex events.