Anthony Davis, Ph.D. received a Bachelor of Science in biochemistry and a Bachelor of Science in microbiology from the University of Oklahoma in 1999. He attended graduate school at UT Southwestern Medical Center (UTSW) and earned a Ph.D. in cell and molecular biology under the mentorship of Marc Mumby, Ph.D., in the Department of Pharmacology. His graduate research focused on the role of protein phosphatase 2A in regulating the early steps of DNA replication.
Dr. Davis did his postdoctoral research under the guidance of David J. Chen, Ph.D., in the Department of Radiation Oncology at UTSW. There, he investigated the cellular response to DNA double-strand breaks (DSBs). In particular, he focused on examining the role that the DNA-dependent protein kinase complex plays in modulating DSB repair pathway choice.
Dr. Davis began his independent research program at UTSW in 2016 in the Division of Molecular Radiation Biology within the Department of Radiation Oncology, where his group continues to investigate the cellular response to DSBs. Furthermore, his group will examine how aberrant DSB repair and signaling promotes tumorigenesis, and how tumors with a dysfunctional DSB response can be preferentially targeted with specific drugs/small molecules. Finally, his group will combine his expertise in DSB repair and protein phosphatases to explore the role of protein phosphatases in modulating the DNA damage response.