May 2020 News

Jin Suk Park 2020 Nominata Award Recipient

Danuser Lab alum and recent graduate from the UTSW Cancer Biology Graduate Program is the 2020 recipient of the Nominata Award, the highest honor for academic and research accomplishment bestowed by the graduate school to an advanced graduate student. Dr. Park will present his thesis work, which was recently published in Nature (see February 2020 News), in a University Lecture Series webinar next Wednesday, May 20, at 4 PM. Dr. Park is now continuing his research career as a postdoctoral research in the lab of Joan Massague╠ü at Memorial Sloan Kettering Cancer Center. UPDATE: Dr. Park was featured in the UT Southwestern Center Times, June 15, 2020. Click here to read the article and watch Dr. Park talk about his experience at UT Southwestern.

XinXin Wang et. al. publish sensitive, unsupervised classifier for endocytosis

Wang et al. developed an unsupervised classification for endocytosis based on a bimodality discovered in the disassembly dynamics of clathrin, recently published in eLife. Clathrin-mediated endocytosis (CME) is the major pathway for cellular uptake of macro-molecular cargo. Imaging approaches allow for observation of the process of clathrin assembly and coated pit maturation, but the mechanistic analysis of CCP dynamics has faced significant limitations. Towards overcoming this analysis hurdle, Wang et. al. developed a a thermodynamics-inspired method, referred to as disassembly asymmetry score classification (DASC). Their validation studies establish DASC as an indispensable tool for comprehensively revealing which endocytic accessory proteins act at specific stages to mediate endocytic coated vesicle formation, functions that were previously not detectable by bulk biochemical measurements.