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Causal inference when perturbations fail

Noh, Isogai et al publish an integrated statistical and experimental pipeline to determine the causal structure of molecular circuitry with significant redundancy and nonlinear interactions among components.

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SH3BP4 -- the link between adhesion and Akt signaling

Christoph Burckhardt discovers how SH3BP4 mediates integrin endocytosis dependent on Akt activity.

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Step off the brakes to get somewhere

Welf et al. discover the necessity of membrane-actin bond release for cell protrusion initiation.

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Mechanometabolism

Park, Burckhardt et al. describe a mechanism through which cells modulate their glucose metabolism based on their mechanical surroundings.

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