Research

Bromodomain-Containing Protein 4 (BRD4)

Human BRD4 Protein Isoforms - Domain Features & Molecular Sizes (SDS-PAGE)
Human BRD4 Protein Isoforms - Domain Features & Molecular Sizes (SDS-PAGE)

Our lab has identified human bromodomain-containing protein 4 (BRD4) as a crucial epigenetic regulator in viral and cellular transcription programming and chromatin dynamics, including DNA replication and genomic maintenance.  Since our first description of BRD4 as an HPV E2 corepressor in suppressing HPV transcription (2006 G&D paper), we have continued to elucidate the functional and biological roles of BRD4 in various biological systems through our own lab research and also collaborative work with scientists and laboratories around the world. 

Our focus on BRD4 is twofold:

  1. BRD4-Regulated Transcription Programs and Cancer Pathways

  2. Therapeutics Targeting Phospho-BRD4