Research

Genetic tools for endometrial cancer

Genetic tools for endometrial cancer research

We identified Sprr2f as an endometrial-specific gene and described methods for using its regulatory regions to drive expression of other genes, such as the Cre recombinase (Sprr2f-Cre). We recently developed an improved version through BAC transgenesis: BAC-Sprr2f-Cre. Our work has shown that this is a useful tool for cancer models (gene knockouts/knockin strategies) to study the roles of specific tumor suppressors/oncogenes in endometrial cancer.