The Biology of VEGF Inhibition

Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis in normal and tumor tissue. Inhibition of VEGF activity results in a decrease of microvessel density, which increases hypoxia in the target tissue. Hypoxia has numerous effects on the tumor microenvironment, including induction of EMT and alterations in metabolism. We are actively working on animals models that recapitulate anti-VEGF induced hypoxia to determine the critical factors that drive 1) resistance to anti-VEGF and 2) changes in tumor cell phenotype after anti-VEGF therapy.