Werner Syndrome Protein and DNA Replication

Our lab is interested in understanding the molecular role of the Werner syndrome protein (WRN) in the suppression of premature aging syndrome, or Werner syndrome (WS). WS is a rare hereditary disease characterized by premature aging and a predisposition to a broad spectrum of rare cancers.

The Werner syndrome protein, which is defective in WS, plays multiple roles in genome stability maintenance pathways; however, WRN mechanisms involved in preventing carcinogenesis at the nucleotide level are poorly understood.

Our lab is interested in deciphering the molecular choreography of WRN and its biochemical activities, post-translational modifications, and interaction partners in the fidelity of replication fork processing. Our ultimate goal is not only to understand the molecular origin of cancer in WS, but also to advance our understanding of the pathophysiology of WS.