Publications

Publications

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Michael A. White, Ph.D. – Principal Investigator

Petes, T., Detloff, P., Jinks-Robertson, S., Judd, R., Kupiec, M., Nag, D., Symington, L., Vincent, A., and White, M. 1989. Recombination in yeast and the recombinant DNA technology. Genome 31, 536-53.

Nag, D., White, M., and Petes, T. 1989. Palindromic sequences in heteroduplex DNA inhibit mismatch repair in yeast. Nature 340, 318-32.

White, M. and Petes, T. 1991. DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. Proc. Natl. Acad. Sci. USA 88, 9755-9759.

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1992 – 1994

Detloff, P., White, M., and Petes, T. 1992. Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae. Genetics 132, 113-123.

Porter, S., White, M., and Petes, T. 1992. Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. Genetics 135, 5-19.

White, M., Detloff, P., Strand, M., and Petes, T. 1992. Transcription stimulates mitotic but not meiotic recombination in yeast. Curr. Gen. 21, 109-116.

White, M., Dominska, M., and Petes, T. 1992. Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90, 6621-6625.

White, M. and Petes, T. 1993. Analysis of meiotic recombination events near a recombination hotspot in the yeast Saccharomyces cerevisiae. Curr. Genet. 26, 21-30.

Xu, H.-P., White, M., Marcus, S., and Wigler, M. 1994. Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Mol. Cell Biol. 14: 50-58.

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1995 – 1996

Van Aelst, L., White, M., and Wigler, M. 1995. RAS partners. Cold Spring Harbor Symp. Quant. Biol. 59: 181-186.

White, M., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., and Wigler, M. 1995. Multiple RAS functions can contribute to mammalian cell transformation. Cell 80: 533-542.

Joneson, T., White, M., Wigler, M., and Bar-Sagi, D. 1995. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of Ras. Science 271: 810-812.

Drugen, J. K., Khosravi-Far, R., White, M., Huang, Y.-W., Der, C., and Campbell, S. 1995. Ras interaction with twodistinct amino binding domains in Raf-1 may be required for Ras transformation. JBC 271: 233-237.

Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M. H., and Der, C. J. 1996. Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways is Sufficient to Cause Tumorigenic Transformation. Mol. Cell. Biol. 16: 3923-3933.

White, M. A., Vale. T., Camonis, J. C., Schaefer, E., and Wigler, M. A. 1996. A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation. J. Biol. Chem. 271: 16439-16442.

White, M. A. 1996. The Yeast Two-Hybrid System: Forward and Reverse. Proc. Natl. Acad. Sci. U. S. A. 93: 10001-10003.

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1997 – 98

Miller, M. J., Prigent, S., Kupperman, E., Rioux, L., Park, S., Feramisco, J. R., White, M. A., Rutkowski, J. L., and Meinkoth, J. L. 1997. RalGDS Functions in Ras- and cAMP-mediated Growth Stimulation. J. Biol. Chem. 272: 5600-5605.

Fan, Q.-Q., Xu, F., White, M. A., and Petes, T. D. 1997. Competition between adjacent meiotic recombination hotspots in the yeast “Saccharomyces cerevisiae”. Genetics 145: 661-670.

Mineo, C., Anderson, R., and White, M. A. 1997. Physical Association with Ras Enhances Activation of Membrane Bound Raf (RafCAAX). J. Biol. Chem. 272: 10345-10348.

Ramocki, M. B., Johnson, S. E., White, M. A., Ashendel, C. L., Konieczny, S. F., and Taparowski, E. J. 1997. Signaling through MAP Kinase and Rac/Rho does not duplicate the effects of Activated Ras on Skeletal Myogenesis. Mol. Cell. Biol. 17: 3547-3555.

Han, L., Wong, D., Dhaka, A., Afar, D., White M .A., Xie, W., Herschman, H., Witte, O., and Colicelli, J. 1997. Protein Binding and Signaling Properties of RIN1 Suggest a Unique Effector Function. Proc. Natl. Acad. Sci. U. S. A. 94: 4954-4959.

White, M. A. 1997. Dissecting the Biological Relevance of Multiple Target Interactions. in: The Yeast Two-Hybrid System. S. Fields (ed.). Oxford University Press.

Han, J.H., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R.D., Krishna, U.M., Falk. J.R., White, M.A., and Broek, D. 1998. Substrates and products of PI3-kinase regulate Vav activation of Rac-related GTPases. Science 279:558-560.

Miller, M.J., Rious, L., Prendergast, G.V., White, M.A., and Meinkoth, J.L. 1998. Differential effects of PKA on Ras effector pathways. Mol. Cell Biol. 18: 3718-3726.

Ramocki, M.B., White, M.A., Konieczny, S.F., and Taparowsky, E.J. 1998. A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J. Biol. Chem. 273: 17696-17701.

Frost, J.A., Khokhlatcheva, A., Stippec, S., White, M.A., Cobb, M.H. 1998. Differential effects of PAK-activating mutations reveal activity-dependent and independend efects of cytoskeletal regulation. J. Biol. Chem. 273: 28191-28198.

Robinson, J.J., Stippic, S.A., Goldsmith, E., White, M.A., and Cobb, M.H. 1998. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr. Biol. 8: 1141-1150.

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1999 – 2000

Morales, C.P., Holt, S.E., Ouellete, M., Kaur, K.J., Ying, Y., Wilson, K.S., White, M.A., Wright, W.E., Shay, J.W. 1999. Lack of cancer-associated changes in human fibroblasts after immortalization with telomerase. Nature Genetics 21: 115-118.

Holt, S.E., Aisner, D.L., Baur, J., Tesmer, V., Dy, M., Ouellette, M., Trager, J., Morin, G., Toft, D., Shay, J.W., Wright, W.E., White, M.A. 1999. Functional requirement of p23 and hsp 90 in telomerase complexes. Genes and Development 13: 817-826.

English, J.M., Pearson, G., Hockenberry, T., Shivakumar, L., White, M.A., and Cobb, M.H. 1999. Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. J. Biol. Chem. 274: 31588-31592.

Wilke, T.M. and White, M.A. 1999. Large and small guanine nucleotide binding proteins - Cellular communication networks. In: Molecular Regulation P. Conn and A. Means (eds.), Totowa, NJ, The Humana Press. In Press.

Henry, D. O., Moskalenko, S., Kaur, K. J., Fu, M., Pestell, R. G., Camonis, J. H. and White, M. A. 2000. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kB. Mol. Cell. Biol 20: 8084-8092.

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2001 – 2002

Vale, T, Ngo, T.T., White, M. A., Lipsky, P. E. 2001. Raf induced transformation requires an interleukin 1 autocrine loop. Cancer Res. 61: 602-607.

Pearson, G., Bumeister, R., Henry, D., Cobb, M., and White, M. A. 2000. Uncoupling Raf from Mek impairs only a subset of cellular responses to Raf activation. J. Biol. Chem. 275: 37303-37306.

Kaur, K. J., and White, M. A. 2001. Isolation of effector selective Ras mutants by yeast two hybrid screening. Methods Enzymol. 332: 220-277.

Pearson, G., English, J. M., White, M. A., and Cobb, M. H. 2001. ERK5 and ERK2 cooperate to regulate NF-{kappa}B and cell transformation. J. Biol. Chem. 276: 7927-7931.

Burbee, D. G., Forgacs, E., Shivakumar, L., Fong, K., Gao, B., Randls, D., Kondo, M., Virmani, A., Bader, S., Sekido, Y., Latif, F. Milchgrub, S., Gazdar, A., Lerman, M., Zabarovsky, E., White, M. A., and Minna, J. 2001. RASSF1A in the 3p21.3 homozygous deletion region: epigentic inactivation in lung and breast cancer and suppression of the malignant phenotype. JNCI 93: 691-699.

White, M. A. and Anderson, R. G. W. 2001. Which Ras rides the raft? Nature Cell Biology 3: E172.

Moskalenko, S., Henry, D., Rose, C. Mirey, C., Camonis, J., and White, M. A. 2002. The exocyst is a Ral effector complex. Nature Cell Biology 4: 66-72.

Anselmo, A. N., Bumeister, R., Thomas, J. M., and White, M. A. 2002. Critical contribution of linker proteins to Raf activation. J. Biol. Chem. 277: 5940-5943

Shivakumar, L., Minna, J., Sakamaki, T., Pestell, R., and White, M. A. 2002. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol. Cell. Biol. 22: 4309-4318.

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2003 – 2004

Chen, W., White, M. A., and Cobb, M. H. 2003, Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J. Biol. Chem. 277: 49105-48110.

D’Amico, M, Wu, K., Di Visio, D., Reutens, A., Stahl, M., Fu, M., Albanese, C., Russell, R. G., Muller, W. J., White, M. A., Negassa, A., Lee, H.-W., DePinho, R., and Pestell, R. G. 2003. The role of INK4a/Arf in ErB2 mammary gland tumorigenesis. Cancer Research, 63: 3395-3402.

Braasch, D. A., Jensen, S., Liu, Y., Kaur, K., Arar, K., White, M. A., and Corey, D. R. 2003. RNA interfer ence in mammalian cells by chemically-modified RNA. Biochemistry 42:7967-7975.

Zhang, W., Zhou, G., Zhao, Y., White, M. A., and Zhao, Y. 2003. Affinity enrichment of plasma membrane for proteomics analysis. Electrophoresis 24:2855-2863.

Chien, Y., and White, M. A. 2003. RalGTPases are linchpin modulators of human tumor cell proliferation and survival. EMBO Rep. 4:800-806.

Zhao, Y., Zhang, W., White, M. A., and Zhao, Y. 2003. Capillary HPLC/Mass spectrometric analysis of proteins from affinity purified plasma membrane. Anal. Chem. 75:3751-3757.

Moskalenko, S., Rosse, C., Mirey, G., Camonins, J., and White, M. A. 2003. Ral GTPases regulate exocyst assembly through dual subunit interactions. J. Biol. Chem., 278:51743-51748.

Matheny, S., Chen, C., Kortum, R., Razidlo, G., Lewis, R., and White, M. A. 2004. Ras regulates assembly of mitogenic signaling complexes through the novel effector protein IMP. Nature, 427: 256-260.

Bumeister, R., Rosse, C., Anselmo, A., Camonis, C., and White, M. A. 2004. CNK2 Couples NGF Signal Propagation to Multiple Regulatory Cascades Driving Cell Differentiation. Current Biology, 14: 439-445.

Zhao, Y., Kwon, S., Anselmo, A., Kaur, K., and White, M. A. 2004. Broad-spectrum identification of cellular SUMO substrate proteins. J. Biol. Chem. 279:20999-21002.

White, M. H-Ras. AfCS-Nature Molecule Pages (2004). (doi:10.1038/mp.a000003.01).

D’Amico, M., Wu, K., Fu, M., Albanese, C., Russell, R. G., Lian, H., Bregman, D., White, M. A., and Pestell, R. G. 2004. The INK4a/ARF locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements. Cancer Res., 64: 4122-4130.

Sunaga, N., Miyajima, K., Suzuki, M., Sato, M., White, M. A., Ramirez, R. D., Shay, J. W., Gazdar, A. F., and Minna, J. D. 2004. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res., 64: 4277-4285.

Abrams, J. M., and White, M. A. 2004. Coordination of cell death and the cell cycle: linking proliferation to death through private and communal couplers. Curr. Opin. Cell Biol., 16: 634-638.

Whitehurst, A., Cobb, M., and White, M. A. 2004. Stimulus-coupled spatial restriction of ERK1/2 activity contributes to the specificity of signal/response pathways. Mol. Cell. Biol., 24:10145-10150.

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2005 – 2006

White, M. A. and Anderson, R. G. W. 2005. Signaling networks in living cells. Ann. Rev. Pharmacol. Toxicol. 45: 587-603.

Camonis, J. H., and White, M. A. 2004. RalGTPases: corrupting the exocyst in cancer. Trends Cell Biol. 15: 327-332.

Formstecher, E., et al. 2005. Protein Interaction Mapping: a Drosophila case study. Genome Res. 15: 376-384.

Matheny, S., and White, M. A. 2005. IMP regulation of KSR and the ERK1/2 cascade. Methods Enzymol. 407: 237-247.

Whitehurst, A., and White, M. A. 2005. RNA interference for analyses of Ras signaling and transformation. Methods Enzymol. 407: 259-268.

Rosse, C., Hatzoglou, A., Parrini, M.C., White, M. A., Cavrier, P. and Camonis, J. 2006. RalB mobilizes the exocyst to drive cell migration. Mol. Cell. Biol. 26:727-734.

Kim, S.C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., Grishin, N., White, M. A., Yang, X.-J., and Zhao, Y. 2006. Substrate and functional diversity of lysine acetylation revealed by proteomics survey. Mol. Cell 23:607-618.

Chien, Y., Kim, S., Kwon, S., Kopelovich, L., Yeaman, C., Zhao, Y., and White, M. A. 2006. RalB GTPase-mediated activation of the IkappaB kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127:157-170.

Balakireva, M., Rosse, C., Chien, Y., Gho, M., White, M. A., and Camonis, J. 2006. The Ral/exocyst effector complex counters JNK-dependent apoptosis in Drosophila. Mol. Cell. Biol. 26:8953-8963.

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2007 – 2008

Whitehurst, A. W., Bodemann, B. O., Cardenas, J., Ferguson, D., Girard, L., Payton, M., Minna, J. D., Michnoff, C., Hao, W., Roth, M. G., Xie, X.-J., and White, M. A. 2007. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446:815-820.

Xie, X.-J., Whitehurst, A., and White, M. 2007. A practical efficient approach in high throughput screening: using FDR and fold change. Nature Protocols, DOI:10.1038/nprot.2007.188.

Komurov, K. and White, M. A. 2007. Revealing static and dynamic modular architecture of the eukaryotic protein interaction network. Molecular Systems Biology 3:110.

Shah, J. K., Garner, H., White, M. A., Shames, D. S., and Minna, J. D. 2007. sIR: siRNA information resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database. BMC Bioinformatics 8:178.

Ganesan, A., Zhao, Y., and White, M. 2007. Broad-spectrum identification of SUMO substrates in melanoma cells. Proteomics 7:2216-2221.

Bodemann, B., and White, M. A. 2008. RalGTPases and cancer: linchpin support of the tumorigenic platform. Nature Reviews Cancer 8:133-140.

Chien, Y. and White, M. A. 2008. Characterization of RalB-Sec5-TBK1 function in human oncogenesis. Methods Enzymol. 438: 321-329.

Chen, C., Lewis, R, and White, M. A. 2008. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J. Biol. Chem. 283: 12789-12796.

Whitehurst, A., Ram, R., Shivakumar, L., Gao, B., Minna, M., and White, M. A. 2008. The RASSF1A Tumor Suppressor Restrains APC/C Activity During the G1/S Phase Transition to Promote Cell Cycle Progression in Human Epithelial Cells. Mol. Cell. Biol. 28: 3190-3197.

Cascone, I., Selmoglu, R., Ozdemir, C., Del Nery, E., Yeaman, C., White, M., and Camonis, J. 2008. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFS. EMBO J. 27: 2375-2387.

Ganesan, A. K., Ho, H., Bodemann, B., Peterson, S., Aruri, J., Koshy, S., Richardson, Z., Le, L., Krasieva, T., Roth, M., Farmer, P., and White, M. A. 2008. Genome-wide siRNA-based functional genomics of pigmentation identifies novel regulatory networks governing melanogenesis in human cells. PLoS Genetics 4:e1000298

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2009 – 2010

Cao, J., Xie, X.-J., Zhang, S., Whitehurst, A., and White, M. A. 2009. Bayesian optimal discovery procedure for simultaneous significance testing. BMC Bioinformatics 10:5.

Matheny S. A., and White, M. A. 2009. Signaling threshold regulation by the Ras effector IMP. J. Biol. Chem. 284:11007-11011.

White, M. A. 2009. Targeting mitotic fragility in cancer. Future Oncology 5: 613-615.

Komurov, K., Gunes, M.H., and White, M. A. 2009. Fine-scale dissection of functional protein network organization by statistical network analysis. PLoS One 4:e6017.

Rosse, C., Formstecher, E., Boeckeler, K., Zhao, Y., Kremerskothen, J., White, M. A., Camonis, J. H., and Parker, P. J. 2009. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localized JNK1 activation. PLoS Bio 7:e1000235.

Balasubramanian, R., Meier, J., Scott, D. W., Norambuena, A., White, M. A., Schwartz, M. A. 2009. The RalA-exocyst complex regulates integrin-dependent plasma membrane localization of raft microdomains and cellular growth signaling. Current Biology 20: 75-79.

Komurov, K., Padron, D., Cheng, T, Roth, M., Rosenblatt, K., and White, M. A. 2010. Comprehensive mapping of the human kinome to EGF Receptor Signaling. J. Biol. Chem. 285:21134-21142.

Komurov, K., White, M. A., Ram, P. 2010. Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data. PLoS Computational Biology 6:e10000889.

Whitehurst, A., Xie, Y., Purinton, S., Cappell, K. M., Swanik, J. T., Girard, L., Schorge, J. O., and White, M. A. 2010. The ACRBP tumor antigen normalizes mitotic spindle function to promote cancer cell proliferation. Cancer Research 70:7652-7661.

The Cancer Target Discovery and Development Network. 2010. Towards patient-based cancer therapeutics. Nature Biotechnology 28: 904-906.

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2011 – 2012

Bodemann, B., Orvedahl, A., Cheng, T., Ram, R., Ou, Y.-H., Formstecher, E., Maiti, M., Hazelett, C., Wauson, E. M., Balakireva, M., Camonis, J., Yeaman, C., Levine, B., and White, M. A. 2011. RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell 144: 253-267.

Ou, Y.-H., Torres, M., Ram. R., Formstecher, E., Roland, C., Cheng., T., Brekken, R., Wurz, R., Tasker, A., Polverino, T., Tan, S.-L., and White, M. A. 2011. TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Molecular Cell 41: 458-470.

Matta, M., Satterly, N., Versteeg, G., Frantz, D., Wei, S., Williams, N., Schmolke, M., Brugarolas, J., Forst, C., White, M.A., Garcia-Sastre A., Roth, M. G., and Fontoura, B. 2011. A novel inhibitor of virus replication prevents activation of mTORC1 via REDD1. Nature Chem Biol 7:712-719.

Esciocak, U., Kim, S. B., Ly, P., Roig, A. L., Biglione, S., Komurov, K., Cornelius, C., Wright, W. E., White, M.A., Shay, J. L. 2011. Functional parsing of driver mutations in the colorectal genome reveals numerous suppressors of anchorage-independent growth. Cancer Research 71: 4359-4365.

Ward, S., Kim, H. S., Komurov K., Saurabh Mendiratta, S., Tsai, P.-L.,Schmolke, M., Satterly, N., Manicassamy, B., Forst, C., Roth, M., García-Sastre, A., Blazewska, K., McKenna, C., Fontoura, B., White, M.A. 2012. Host modulators of H1N1 cytopathogenicity. PLoS One, 7(8):e39284.

Herman, M., Ciancancelli, M., Ou, Y.-H., Lorenzo, L., Klaudel-Dreszler, M., Pauwels, E., Sancho-Shimizu, V., Pérez de Diego, R., Abhyankar, A., Israelsson, L., Guo, Y,Cardon, A., Rozenberg, F., Lebon, P., Tardieu, M., Heropolitańska-Pliszka, M., Chaussabel, D., White, M.A., Abel, L., Zhang, S., and Casanova, J.-L. 2012. Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J. Exper. Med. 209: 1567-1582.

Pathak, R., Anselmo, A., White, M.A., DerMardirossian, C., Bokoch, G. 2012. The Microtubule-associated Rho Activating Factor GEF-H1 interacts with Exocyst complex to regulate Vesicle Traffic. Dev. Cell 23:397-411.

Pathak, R., Anselmo, A., White, M.A., DerMardirossian, C., Bokoch, G. 2012. The Microtubule-associated Rho Activating Factor GEF-H1 interacts with Exocyst complex to regulate Vesicle Traffic. Dev. Cell 23:397-411.

Ho, H., Aruri, J., Kapadia, R., Mehr, H., White, M. A., and Ganesan A. K. 2012. RhoJ and Pak kinases regulate melanoma chemoresistance by suppressing pathways that sense DNA damage.  Cancer Research 72: 5516-5528.

Wang, R. C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., White, M., Reichelt, J., and Levine, B. 2012. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 338:956-959.

Yarborough, M. L., White, M. A., and Fontoura, B. M. 2012. Shaping the p53 response with nucleoporins. Molecular Cell 48: 665-666.

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2013 – 2014

Potts, M., Kim, H., Fisher, K., Hu, Y., Carrasco, Y., Ou, Y., Herrera, M., Cubillos, F., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Lewis, R., MacMillan, J, and White, M.A. 2013. Using Functional Signature Ontology (FuSiOn) to identify mechanisms of action for natural products. Science Signaling 6:ra90.

Hu Y., Potts, M. B., Colosimo, D., Herrere-Herrera, M. L., Legako, A. G., Yousufuddin, M., White, M. A., and MacMillan, J. B. 2013. Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. J. Am. Chem. Soc. 135: 13387-13392.

Kim H, Mendiratta S, Kim J, Pecot C, Larsen J, Zubovych I, Seo B, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs J, Wei S, Peyton M, Williams N, Gazdar A, Posner B, Brekken R, Sood A, Deberardinis R, Roth M, Minna M, and White M. A. 2013. Systematic identification of molecular subtype-selective vulnerabilities in non small cell lung cancer. Cell 155: 552-66.

Cooper, J. M., Bodemann, B. O., and White, M. A. 2013. The RalGEF/Ral pathway: evaluating an intervention opportunity for Ras cancers. The Enzymes 34: 137-157.

Bodemann, B. O. and White, M. A. 2013. RasGTPases: codon bias holds KRas down but not out. Current Biology 23:R17-20.

Kim, H.-S., Minna, J, and White M. A. 2013. GWAS meets TCGA to illuminate mechanisms of cancer predisposition. Cell 152: 387-389.

Rifki O. F., Bodemann, B. O., Battiprolu, P. K., White, M. A., and Hill, J. A. 2013. RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy. J. Mol. Cell. Cardiol. 59:128-138.

Singh, N.K., Seo, B.Y., Vidyasagar, M., White, M. A., and Kim, H.S. 2013. SiMacro: a fast and easy data processing tool for cell-based genome-wide siRNA screens. Genomics Inform. 11:55-57.

Tang, H., Xiao, G., Behrens, C., Schiller, J., Allen, J., Chow, C. W., Suraokar, M., Corvalan, A., Mao, J., White, M. A., Wistuba I. I., Minna, J. D. and Xie, Y. 2013. A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin. Cancer Res. 19: 1577-1586.

Zhong, R., Kim, M. S., White, M. A., Xie, Y., and Xiao, G. 2013. SbacHTS: spatial background noise correction for high throughput RNAi screening. Bioinformatics 29:2218-2220.

Mor, A., White, M. A., Fontoura, B. 2014. Nuclear trafficking in health and disease. Current Opinion in Cell Biology 28: 28-35.

Ram, R.R., Mendiratta, S., Bodemann, B.O., Torres, M.J., Eskiocak, U., and White, M.A. 2014. RASSF1A-inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol. Cell. Biol. 34: 2350-2358.

Zhong, R., Kim, J., Kim, H., Kim, M., Lum, L., Levine, B., Xiao, G., White, M. A.*, and Xie, Y*. Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens.  Nucleic Acids Research, in press.  * co-corresponding authors

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