Reseach Interests
Dr. Vongpatanasin's research interest is in the area of neural control of blood pressure and the influence of various hormones and antihypertensive agents on the autonomic control of blood pressure in humans. Her laboratory has performed autonomic studies in both normal healthy subjects and patients with hypertension or autonomic dysfunction.
Clinical trial: Diuretic treatment for high blood pressure
| Ad Title: | Diuretic treatment for high blood pressure | ||||
| Study Title: | Neural Mechanisms of Thiazide Diuretics-Induced Insulin Resistance | ||||
| Protocol Number: | 022004-016 | ||||
| Department(s) involved in the Study: | Int Med - Cardiology, Internal Medicine | ||||
| Purpose of the Study: | To determine if currently approved medication treatment for high blood pressure have different effects on the nerve activity which controls blood pressure and blood sugar levels | ||||
| Participant Eligibility: | Men and women aged 18-65 with high blood pressure between 140-149/90-99 mmHg.Study excludes subjects with heart diseases, diabetes mellitus, lung disease, cancer, and thyroid problems. | ||||
| Disease/Condition Under Study: | Hypertension, high blood pressure, insulin resistance | ||||
| Cancer Related Study: | No | ||||
| Study Drug(s): | chlorthalidone, clonidine hydrochloride, eplerenone, insulin, irbesartan, phenylephrine hydrochloride, quinapril, Sodium nitroprusside, spironolactone | ||||
| Study Device(s): | |||||
| Study Doctor: | Wanpen Vongpatanasin, M.D. | ||||
| Location of Study: |
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| Contact Phone: | 214-648-2968 | ||||
| Email: | debbie.arbique@utsouthwestern.edu | ||||
| Other Information: | Medications will be provided free of charge. Participants will be compensated for their time. | ||||
| Website Keywords: | Vascular | ||||
| Medical Keywords: | diuretics, high blood pressure, hypertension, insulin resistance |
Publications
Abbas A, Szczepaniak LS, Tuncel M, McGavock JM, Adams-Huet B, Fadel PJ, Wang Z, Arbique D, Victor R, Vongpatanasin W. Adiposity-independent sympathetic activity in black men. J Appl Physiol. 2010 Mar 18. [Epub ahead of print]
Vongpatanasin W. Autonomic regulation of blood pressure in menopause. Semin Reprod Med. 2009 Jul;27(4):338-45. Epub 2009 Jun 15. Review
Menon DV, Arbique D, Wang Z, Adams-Huet B, Auchus RJ, Vongpatanasin W. Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients. J Clin Endocrinol Metab. 2009 Apr;94(4):1361-6. Epub 2009 Jan 21.
Fu Q, Vongpatanasin W, Levine BD. Neural and nonneural mechanisms for sex differences in elderly hypertension: can exercise training help? Hypertension. 2008 Nov;52(5):787-94. Epub 2008 Oct 13.Review.
Vongpatanasin W. Management of hypertension in patients with coronary artery disease. Curr Hypertens Rep. 2008 Oct;10(5):349-54. Review.
Vongpatanasin W. Cardiovascular morbidity and mortality in high-risk populations: epidemiology and opportunities for risk reduction. J Clin Hypertens (Greenwich). 2007;9:11-5.
Menon DV, Wang Z, Fadel PJ, Arbique D, Leonard D, Li J-L, Victor RG, Vongpatanasin W. Central Sympatholysis as a Novel Countermeasure for Cocaine-Induced Sympathetic Activation and Vasoconstriction in Humans. J Am Coll Cardiol 2007;50:626–33.
Auchus RJ, Chandler DW, Singeetham S, Chokshi N, Nwariaku FE, Dolmatch BL, Holt SA, Wians Jr FH, Josephs SC, Trimmer CK, Lopera J, Vongpatanasin W, Nesbitt SD, Leonard D, Victor RG. Differential Diagnosis of Primary Aldosteronism Based on Adrenal Vein 18-Hydroxycorticosterone Concentrations. J Clin Endo 2007 ;92(7):2648-51.
Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, Zhu W, Word RA, Seetharam D, Black S, Samols D, Mineo C, Shaul PW. C-reactive Protein Downregulates Endothelial NO Synthase and Attenuates Reendothelialization In Vivo in Mice. Circ Res 2007;100(10):1452-9.
Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, and Shaul PW. CRP Causes Downregulation of Vascular AT2 Receptors and Systolic Hypertension in Mice. Circulation 2007;115(8):1020-8.
Ashraf M, Vongpatanasin W. Estrogen and Hypertension. Current Hypertension Reports 2006;8:368-76
Nwariaku FE, Miller BS, Auchus R, Holt S, Watumull L, Dolmatch B, Nesbitt S, Vongpatanasin W, Victor R, Wians F, Livingston E, Snyder WH 3rd. Primary hyperaldosteronism: effect of adrenal vein sampling on surgical outcome. Arch Surg. 2006;141:497-503.
Li JL, Canham RM, Vongpatanasin W, Leonard D, Auchus, RJ, Victor, RG. Do Allelic Variants in alpha 2A and alpha 2C Adrenergic Receptors Predispose to Hypertension in Blacks? Hypertension. 2006 47:1140-6.
Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I . Circ Res. 2006;98:63-72.
Menon DV, Vongpatanasin W. Effects of transdermal estrogen replacement therapy on cardiovascular risk factors. Treat Endocrinol. 2006;5:37-51.
Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR, Vongpatanasin W, Wians FH Jr, Grundy SM, de Lemos JA. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005;46:464-9.