About Us

Affiliated Faculty

 

Rajiv Chopra

Rajiv Chopra, Ph.D.​

Associate Professor​
Department of Radiology, UT Southwestern​
NE6.252, 214-648-7745​
Rajiv.Chopra@UTSouthwestern.edu
Lab website

Dr. Chopra’s research is concentrated on the development of image-guided therapies. In particular, he has focused on the biomedical applications of high-intensity focused ultrasound (HIFU). Ultrasound is an attractive form of energy for therapeutic use because it can be transmitted through the body from external transducers, can be focused to very localized regions of a few millimeters, and can be generated from devices of multiple geometries ranging from large focused transducers to catheter-based devices. A unique set of capabilities arises when this technology is combined with magnetic resonance imaging (MRI). The ultrasound technology is able to deliver energy within the body noninvasively for applications such as mild heating or tissue ablation, and MRI is able to acquire images of the temperature distribution in the heated tissues during heating. Since the relationship between temperature, time and cell kill is well established, this creates a powerful closed loop method for treating soft tissues.​

The other emerging application of HIFU is to potentiate or enable targeted delivery of agents within the body. Ultrasound can be used to trigger release from temperature-sensitive liposomes, or to noninvasively open the blood/brain barrier. These capabilities offer many possibilities for targeted drug delivery in the brain and other organs with pre-existing vascular barriers (retina, testicles, placenta, etc).​

Dr. Chopra’s research has a preclinical component focused on novel applications of HIFU, and a translational component aimed at evaluating established HIFU approaches in patients.​


 

Mi Deng

Mi Deng, Ph.D.​

Assistant Professor​
Department of Radiology and Department of Physiology, UT Southwestern​
Mi.Deng@UTSouthwestern.edu

Mi Deng, Ph.D., holds a bachelor's degree in biotechnology (2004) and a master's degree in developmental biology (2007) from Hunan Normal University in China. He then earned a doctorate in biochemistry and molecular biology (2012) from the University of Nebraska Medical Center. His doctoral research was on gene transcriptional regulation, protein post-translational modification and cellular signaling transduction. Dr. Deng joined UT Southwestern in 2012 as a postdoctoral researcher in Dr. Alec Zhang’s laboratory, where he investigated the biology and translational applications of hematopoietic and leukemia stem cells. He then joined the Physiology Department faculty as an Instructor. His current research is focused on the biology of tumor microenvironment, and translational oncology of therapeutic antibody development and cell-based immunotherapy.​ Dr. Deng became Assistant Professor​ in May 2017.


 

David Fetzer

David Fetzer, M.D.

Assistant Professor​
Medical Director of Ultrasound​
Department of Radiology, UT Southwestern​
NE6.236, 214-648-7770​
David.Fetzer@UTSouthwestern.edu

David Fetzer's complimentary background in imaging science and interest in translational research constitute the basis for his work in multimodality testing and quantitative imaging, particularly in metabolic, hepatobiliary, pancreatic, thyroid, and lymph node imaging.  ​

Dr. Fetzer is also Director of the Collaborative for Advanced Clinical Techniques in Ultrasound (CACTUS), a clinical laboratory drawing upon expertise from radiologists, medical physicists, industry partners, and various medical specialists focused on cutting edge clinical care and establishing an environment for clinical and translational research in ultrasound.​


 

Matthew Lewis

Matthew Lewis, Ph.D.

Assistant Professor​
Department of Radiology, UT Southwestern​
NE6.250, 214-648- 7751​
Matthew.Lewis@UTSouthwestern.edu