Publications

Publications


Click here to see a complete list of Articles and Communications.

Click here to see a complete list of Book Chapters, Perspectives, and Reviews.

 

Articles and Communications
 

33. Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block. Liela Bayeh, Phong Q. Le, and Uttam K. Tambar. Nature 2017, 546, 196-200.

32. Copper-Catalyzed Enantioselective, Diastereoselective, and Regioselective [2,3]-Rearrangements of Iodonium Ylides. Bin Xu and Uttam K. Tambar. Angew. Chem. Int. Ed. 2017, 56, Accepted.

31. Copper-Catalyzed Aminothiolation of 1,3-Dienes via a Dihydrothiazine Intermediate. Christopher E. Sleet and Uttam K. Tambar. Angew. Chem. Int. Ed. 2017, 56, 5536-5540.

30. Copper-catalyzed [1,2]-rearrangements of allylic iodides and aryl α-diazoacetates. Bin Xu, Jackson A. Gartman, and Uttam K. Tambar. Tetrahedron 2017, 73, 4150-4159. (Invited contribution for a special issue of Tetrahedron Symposia-in-Print on 'New Advances in Pericyclic Reactions.')

29. Ligand-Controlled Regiodivergence in the Copper-Catalyzed [2,3]- and [1,2]-Rearrangements of Iodonium Ylides. Bin Xu and Uttam K. Tambar. J. Am. Chem. Soc. 2016138, 12073-12076.

28. Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Thomas H. Scheuermann, Daniel Stroud, Christopher E. Sleet, Liela Bayeh, Cameron Shokri, Hanzhi Wang, Charles G. Caldwell, Jamie Longgood, John B. MacMillan, Richard K. Bruick, Kevin H. Gardner, and Uttam K. Tambar. J. Med. Chem. 201558, 5930-5941.

27. Palladium-catalyzed cross-coupling of α-bromocarbonyls and allylic alcohols for the synthesis of α-aryl dicarbonyl compounds. Yang Yu and Uttam K. Tambar. Chem. Sci. 20156, 2777-2781.

26. Bis(phenylsulfonyl)sulfur Diimide. Liela Bayeh and Uttam K. Tambar. e-EROS Encyclopedia of Reagents for Organic Synthesis. 2015, 1-3.

25. Regioselective and diastereoselective aminoarylation of 1,3-dienes. Hongli Bao, Liela Bayeh, and Uttam K. Tambar. Chem. Sci. 20145, 4863-4867.

24. Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase. Shih-Chia Tso, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Xiangbing, Qi, Kristen J. Skvorak, Kenneth Dorko, Amy L. Wallace, Lorraine K. Morlock, Brendan H. Lee, Susan M. Hutson, Stephen C. Strom, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang. J. Biol. Chem. 2014289, 20583-20593.

23. Allylic Functionalization of Unactivated Olefins with Grignard Reagents. Hongli Bao, Liela Bayeh, and Uttam K. Tambar. Angew. Chem. Int. Ed. 201453, 1664-1668. (German Edition)

22. Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn and David T. Chuang. J. Biol. Chem. 2014289, 4432-4443.

21. Brønsted Acid Catalyzed Enantioselective Indole Aza-Claisen Rear-rangement Mediated by an Arene CH-O Interaction. Pradip Maity, Ryan P. Pemberton, Dean J. Tantillo, and Uttam K. Tambar. J. Am. Chem. Soc. 2013135, 16380-16383. (This article was featured in Synfacts.)

20. Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ­ent-Sitagliptin. Hongli Bao, Liela Bayeh, Uttam K. Tambar. Synlett 201324, 2459-2463. (Invited contribution for the Young Investigator Workshop. This article was featured as the SYNFACT of the month.)

19. Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement. Arash Soheili and Uttam K. Tambar. Org. Lett. 201315, 5138-5141. (This article was featured in Organic Highlights.)

18. Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]-Stevens Rearrangement and Ring-Closing Metathesis. Aaron Nash, Arash Soheili, and Uttam K. Tambar. Org. Lett. 201315, 4770-4773.

17. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynna, and David T. Chuang. Proc. Natl. Acad. Sci. U.S.A. 2013110, 9728-9733. (This article was featured in SciBX.)

16. Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor. Jamie L. Rogers, Liela Bayeh, Thomas H. Scheuermann, Jamie Longgood, Chuck Caldwell, Jason Key, Jacinth Naidoo, Lisa Melito, Cameron Shokri, Doug E. Frantz, Richard K. Bruick, Kevin H. Gardner, John B. MacMillan, and Uttam K. Tambar. J. Med. Chem. 201356, 1739-1747.

15. Allosteric Inhibition of Hypoxia Inducible Factor 2 with Small Molecules. Thomas H. Scheuermann, Qiming Li, He-Wen Ma, Jason Key, Lei Zhang, Rui Chen, Joseph A. Garcia, Jacinth Naidoo, Jamie Longgood, Douglas E. Frantz, Uttam K. Tambar, Kevin H. Gardner, and Richard K. Bruick. Nat. Chem. Biol. 20139, 271-276.

14. Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement. Hongli Bao and Uttam K. Tambar. J. Am. Chem. Soc. 2012134, 18495-18498(This article was featured in the Editors’ Choice section of ScienceSynfactsSynform, and Organic Highlights.)

Our chemistry is highlighted on the Sigma-Aldrich Website.

13. Tandem Catalytic Allylic Amination and [2,3]-Stevens Rearrangement of Tertiary Amines. Arash Soheili and Uttam K. Tambar. J. Am. Chem. Soc. 2011133, 12956-12959. (This article was featured in Synfacts.)

12. SYNPACTS: Stereoselective [2,3]-Rearrangements of Amine N-Oxides. Hongli Bao, Xiangbing Qi, and Uttam K. Tambar. Synlett 2011, 1789-1792. (Invited contribution for SYNPACTS.)

11. Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine. Xiangbing Qi, Hongli Bao, and Uttam K. Tambar. J. Am. Chem. Soc. 2011133, 10050-10053.

10. Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides. Hongli Bao, Xiangbing Qi, and Uttam K. Tambar. J. Am. Chem. Soc. 2011133, 1206-1208. (This article was featured in Synfacts.)

 

Graduate and Postdoctoral Publications:

 

9. Enantioselective (Formal) Aza-Diels-Alder Reactions with Non-Danishefsky-Type Dienes. Uttam K. Tambar , Sharon K. Lee, and James L. Leighton. J. Am. Chem. Soc. 2010132, 10248-10250. (This article was featured in Synfacts.)

8. Highly enantioselective formal aza-Diels–Alder reactions with acylhydrazones and Danishefsky’s diene promoted by a silicon Lewis acid. Sharon K. Lee, Uttam K. Tambar, Nicholas R. Perl, and James L. Leighton. Tetrahedron 201066, 4769-4774. (This article was featured in Synfacts.)

7. The Direct Acyl-Alkylation of Arynes. Preparation of Methyl 2-(2-Acetylphenyl)Acetate. David C. Ebner, Uttam K. Tambar, Brian M. Stoltz. Org. Synth. 200986, 161-171.

6. Pd-Catalyzed Enantioselective Aerobic Oxidation of Secondary Alcohols: Applications to the Total Synthesis of Alkaloids. Shyam Krishnan, Jeffrey T. Bagdanoff, David C. Ebner, Yeeman K. Ramtohul, Uttam K. Tambar, Brian M. Stoltz. J. Am. Chem. Soc. 2008130, 13745-13754.

5. The development and scope of a versatile tandem Stille-oxa-electrocyclization reaction. Uttam K. Tambar, Taichi Kano, John F. Zepernick and Brian M. Stoltz. Tetrahedron Lett. 200748, 345-350.

4. Convergent and Diastereoselective Synthesis of the Polycyclic Pyran Core of Saudin. Uttam K. Tambar, Taichi Kano, John F. Zepernick, and Brian M. Stoltz, J. Org. Chem. 200671, 8357-8364.

3. A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C-H and C-C Bond Insertion ReactionsUttam K. Tambar, David C. Ebner, and Brian M. Stoltz, J. Am. Chem. Soc. 2006128, 11752-11753. (This publication was listed as one of the ten most accessed communications in J. Am. Chem. Soc. for the July-September 2006 period. This paper was also featured in Synfacts.)

2. Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction. Uttam K. Tambar, Taichi Kano, and Brian M. Stoltz, Org. Lett. 20057, 2413-2416.

1. The Direct Acyl-Alkylation of Arynes. Uttam K. Tambar and Brian M. Stoltz, J. Am. Chem. Soc. 2005127, 5340-5341.

 

 

Book Chapters, Perspectives, and Reviews

3. Brønsted acid catalyzed enantioselective pericyclic reactionsChristopher E. Sleet, Uttam K. Tambar, and Pradip Maity. Tetrahedron 2017, 73, 4023-4038. (Invited contribution for a special issue of Tetrahedron Symposia-in-Print on 'New Advances in Pericyclic Reactions.')

2. Hongli Bao and Uttam K. Tambar, "[2,3]-Rearrangements of Ammonium Zwitterions." In Molecular Rearrangements in Organic Synthesis, (Eds.: C. M. Rojas), John Wiley & Sons, New Jersey, USA, 2016, pp. 459-496. (This book was "highly recommended" by a reviewer in Angewandte Chemie International Edition.)

1. Chapter 6 - Synthesis of (±)-Amathaspiramide F: Stereochemical Switch of a [2,3]-Stevens Rearrangement. Arash Soheili, Carrie Johnson, and Uttam K. Tambar. Strategies and Tactics in Organic Synthesis 2014, 10, 131-154.