Publications

Publications from Ready Group

Palladium Catalyzed Asymmetric Three-Component Coupling of Boronic Esters, Indoles, and Allylic Acetates.
Panda S, Ready JM. J Am Chem Soc. 2017; 139:6038-6041. doi: 10.1021/jacs.7b01410.

Rhodium-Catalyzed Enantioselective Radical Addition of CX4 Reagents to Olefins.
Chen B, Fang C, Liu P, Ready JM. Angew Chem Int Ed Engl. 2017; 56:8780-8784. doi: 10.1002/anie.201704074.

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Kishore AH, Liang H, Kanchwala M, Xing C, Ganesh T, Akgul Y, Posner B, Ready JM, Markowitz SD, Word RA. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6427-E6436. doi: 10.1073/pnas.1704945114.

Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies.
Zhang W, Ready JM. Nat Prod Rep. 2017 34: 1010-1034. doi: 10.1039/c7np00018a.

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.
Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM. J Med Chem. 2017 60: 3979-4001. doi: 10.1021/acs.jmedchem.7b00271.

A Concise Total Synthesis of Dictyodendrins F, H, and I Using Aryl Ynol Ethers as Key Building Blocks.
Zhang W, Ready JM. J Am Chem Soc. 2016; 138:10684-92. doi: 10.1021/jacs.6b06460. 

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.
Rujirawanich J, Kim S, Ma AJ, Butler JR, Wang Y, Wang C, Rosen M, Posner B, Nijhawan D, Ready JM. J Am Chem Soc. 2016;138:10561-70. doi: 10.1021/jacs.6b05484

Zirconcene-mediated carbonylative coupling of Grignard reagents.
Moss M, Han X, Ready JM. Angew Chem Int Ed. 2016 Aug 16;55(34):10017-21. doi: 10.1002/anie.201603133

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates.
Winterton SE, Ready JM. Org Lett. 2016 Jun 3;18(11):2608-11

 

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Nat Chem Biol. 2016 Apr;12(4):218-25

Synthesis and Utility of Dihydropyridine Boronic Esters.
Panda S, Coffin A, Nguyen QN, Tantillo DJ, Ready JM. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2205-9. 

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD. Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340

  

Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.
Chen J, Koswatta P, DeBergh JR, Fu P, Pan E, MacMillan JB, Ready JM. Chem Sci. 2015 May 1;6(5):2932-2937. 

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM. Mol Psychiatry. 2015 Apr;20(4):500-8.

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.
De Jesús-Cortés H, Miller AD, Britt JK, DeMarco AJ, De Jesús-Cortés M, Stuebing E, Naidoo J, Vázquez-Rosa E, Morlock L, Williams NS, Ready JM, Narayanan NS, Pieper AA.
NPJ Parkinsons Dis. 2015;1. pii: 15010.

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage.
Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL Cell2014 Sep 158 6 1324-34

Pharmacologic Rescue of Motor and Sensory Function by the Neuroprotective Compound P7C3 Following Neonatal Nerve Injury.
Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, H Borschel G Neuroscience 2014 Oct

P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury.
Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AACell Rep 2014 Sep 8 6 1731-40

The Ketene-Surrogate Coupling: Catalytic Conversion of Aryl Iodides into Aryl Ketenes through Ynol Ethers.
Zhang W, Ready JM Angew. Chem. Int. Ed. Engl. 2014 Jun

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with Improved Druglike Properties.
Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM J. Med. Chem. 2014 Apr

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases.
Pieper AA, McKnight SL, Ready JM Chem Soc Rev 2014 Feb

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM Mol. Psychiatry 2014 Apr

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK J Mol Biol 2014 May 426 2045-58. 

Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α.
Wang Y, Wang C, Butler JR, Ready JM. Angew Chem Int Ed Engl. 2013 Oct 52 10796-9

On the rapid oxidation of allene-containing phosphines.
Cai F, Thangada ND, Pan E, Ready JM. Organometallics 2013 32 5619-22.

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.
Kilgore JA, Du X, Melito L, Wei S, Wang C, Chin HG, Posner B, Pradhan S, Ready JM, Williams NS J. Biol. Chem. 2013 May 288 19673-84.

Development of scalable synthesis of P7C3-A20, a potent neuroprotective agent.
Naidoo J, Bemben CJ, Allwin SR, Lian J, Pieper AA, Ready JM. Tetrahedron Lett 2013 54 4429-4432.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.
De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 42 17010-5

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.
Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 42 17016-21

Cyclocondensation of amino-propargyl silanes.
Wang Y, Ready JM Org. Lett. 2012 May 14 9 2308-11

Two-, three-, and four-component coupling to form isoquinolones based on directed metalation.
Antczak M, Ready JM. Chem Sci 2012 3 1450-1454.

Chiral allene-containing phosphines in asymmetric catalysis.
Cai F, Pu X, Qi X, Lynch V, Radha A, Ready JMJ Am Chem Soc. 2011 Nov 133 18066-9.

Enantioselective total synthesis of (-)-kibdelone C.
Butler JR, Wang C, Bian J, Ready JM. J Am Chem Soc 2011 Jul 133 9956-9.

Titanium-mediated oxidative arylation of homoallylic alcohols.
Lee KS, Ready JM. Angew Chem Int Ed Engl. 2011 Feb 50 2111-4

Development of proneurogenic, neuroprotective small molecules.
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. J Am Chem Soc. 2011 Feb 133 1428-37

Asymmetric synthesis of tertiary benzylic alcohols.
Antczak MI, Cai F, Ready JM. Org Lett. 2011 Jan 13 84-7.

Discovery of a proneurogenic, neuroprotective chemical.
Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Cell. 2010 Jul 142 39-51.

Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC).
Espindola AP, Crouch R, DeBergh JR, Ready JM, MacMillan JB. J Am Chem Soc. 2009 Nov 131 15994-5.

Allenes in asymmetric catalysis: asymmetric ring opening of meso-epoxides catalyzed by allene-containing phosphine oxides.
Pu X, Qi X, Ready JM. J Am Chem Soc. 2009 Aug 131 10364-5

Synthesis of cyclopentenones from cyclopropanes and silyl ynol ethers.
Qi X, Ready JM. Angew Chem Int Ed Engl. 2008 47 7068-70.

Direct and stereospecific synthesis of allenes via reduction of propargylic alcohols with Cp2Zr(H)Cl.
Pu X, Ready JM. J Am Chem Soc. 2008 Aug 130 10874-5.

Preparation of substituted enol derivatives from terminal alkynes and their synthetic utility.
DeBergh JR, Spivey KM, Ready JM. J Am Chem Soc. 2008 Jun 130 7828-9.

Directed Hydrozirconation of Homopropargylic Alcohols.
Liu X, Ready JM. Tetrahedron. 2008 64 6955-6960.

Directed hydrozirconation of propargylic alcohols.
Zhang D, Ready JM. J Am Chem Soc. 2007 Oct 129 12088-9.

Discovery of small-molecule inhibitors of tyrosinase.
Germanas JP, Wang S, Miner A, Hao W, Ready JM. Bioorg Med Chem Lett. 2007 Dec 17 6871-5.

Copper-promoted cycloaddition of diazocarbonyl compounds and acetylides.
Qi X, Ready JM. Angew Chem Int Ed Engl. 2007 46 3242-4.

Iron-catalyzed carbometalation of propargylic and homopropargylic alcohols.
Zhang D, Ready JM. J Am Chem Soc. 2006 Nov 128 15050-1.

Enantioselective total synthesis of (+)- and (-)-nigellamine A2.
Bian J, Van Wingerden M, Ready JM. J Am Chem Soc. 2006 Jun 128 7428-9.

Tandem carbocupration/oxygenation of terminal alkynes.
Zhang D, Ready JM. Org Lett. 2005 Dec 7 5681-3.

Catalytic cross-coupling of alkylzinc halides with alpha-chloroketones.
Malosh CF, Ready JM. J Am Chem Soc. 2004 Aug 126 10240-1.