Publications

Selected Publications

  1. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. (2017) Stender S., Kozlitina J., Nordestgaard B.G., Tybjaerg-Hansen A., Hobbs H.H., Cohen J.C. Nature Genet. in press PMCID: PMC Journal – In Process
  2. Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin. (2017) Chakrabarti R.S., Ingham S.A., Kozlitina J., Gay A., Cohen J.C., Radhakrishnan A., Hobbs H.H eLife: doi: 10.7554/elife.23355. PMCID: PMC5323040
  3. Crystal structure of the human sterol transporter ABCG5/ABCG8. (2016) Lee J.-Y., Kinch L.N., Borek D.M., Wang J., Urbatsch I.L., Xie X.-S., Grishin N.V., Cohen J.C., Otwinowski Z., Hobbs H.H., Rosenbaum D.M. Nature: 533: 561-564. PMCID: PMC4964963
  4. Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. (2015) Wang Y., McNutt M., Banfi S., Levin M., Holland W.L., Gusarova V., Gromada J., Cohen J.C., Hobbs H.H. Proc. Natl. Acad. Sci. USA 112:11630-11635. PMCID: PMC4479334
  5. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. (2015) Mitsche M.A., McDonald J.G., Hobbs H.H., Cohen J.C. eLife 4: e07999. PMCID: PMC4501332
  6. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. (2014) Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, Tybjærg-Hansen A, Vogt TF, Hobbs H. H., Cohen J.C. Nat Genet. 2014 Apr;46(4):352-6.PMCID: 24531328
  7. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. (2013) Wang Y., Quagliarini F., Gusarova V., Gromada J., Valenzuela D.M., Cohen J.C.Hobbs H.H.  Proc. Natl. Acad. Sci. USA., in press  PMCID: PMC Journal – In Process
  8. Simple genetics for a complex disease. (2013) Cohen J.C. and Hobbs H.H.  Science 340: 2013-2014.   PMCID: PMC Journal – In Process
  9. Atypical angiopoietin-like protein that regulates ANGPTL3. (2012) Quagliarini F., Wang Y., Kozlitina J., Grishin N.V., Hyde R., Boerwinkle E., Valenzuela, D.M., Murphy A.J., Cohen J.C., and Hobbs H.H.  Proc. Natl. Acad. Sci. USA, 109:19751-19756. PMCID: PMC3511699
  10. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.  (2008) Romeo S., Kozlitina J., Xing C., Pertsemlidis A., Cox D., Pennacchio L.A., Boerwinkle E., Cohen J.C.Hobbs, H.H.  Nat. Genet. 40: 1461-1465.  PMCID: PMC2597056
  11. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. (2006) Cohen J.C., Boerwinkle E., Mosley T.H., Hobbs H.H.  N. Engl. J. Med. 354: 1264-1272.
  12. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. (2004) Cohen J.C., Kiss R.S., Pertsemlidis A., Marcel Y.L., McPherson R., Hobbs H.H.  Science 305:869-872.