Prosthetic joint infection is a major challenge in the field of joint arthroplasty due to the presence of bacterial biofilm on infected implants. While the risk of developing a post-surgical prosthetic joint infection is estimated to occur in 1-2 percent of patients, the current treatment paradigm of antibiotics and prosthetic joint resection/replacement is prolonged, invasive, and expensive. The most prevalent Gram-negative and Gram-positive organisms isolated from these infected implants are Pseudomonas aeruginosa and Staphylococcus aureus. In 2017, the WHO released a list of the most dangerous superbugs, with P. aeruginosa classified as a critical priority and S. aureus as a high priority for new antimicrobial development. We utilize a multidisciplinary approach, combining the expertise of our lab and the Chopra laboratory, utilizing antibiotics and an Alternating Magnetic Field (AMF) to disrupt implant associated biofilms.