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About Us

Lab Personnel

Dr. Goldsmith

Elizabeth J. Goldsmith graduated from UCLA with Honors in Chemistry and completed a Ph.D. in Physical Chemistry at UCLA in 1972, receiving recognition as Graduate Woman of the Year. She did postdoctoral work at the MRC laboratory in Cambridge, England, and at the University of California, San Francisco, and has been on faculty in the Department of Biochemistry, UT Southwestern Medical Center, since 1987. Her laboratory uses crystallographic methods to understand how proteins are regulated by conformational changes.


Dr. Radha

Radha Akella received her Ph.D. from the Indian Institute of Technology, Madras, in 1988. She did postdoctoral work in the Department of Food Science at Purdue University, working on X-ray fiber diffraction of nucleic acids and polysaccharides. Currently, she is an Instructor in the Department of Biochemistry at UT Southwestern Medical Center. She works on small molecule and protein crystallography of MAP kinases.


Dr. Humphreys

John M. Humphreys earned bachelor’s degrees in Biochemistry and Plant Pathology at Ohio State University. He then earned his Ph.D. in Biochemistry from Purdue University, where he worked on cytochrome P450s in plant secondary metabolism. He is currently a research scientist and studies the biochemistry and structural biology of MAP kinase cascades.


Alex Piala

Alex T. Piala received his B.S. in biochemistry from the State University of New York at Binghamton in 2006, and received his M.S. in chemistry from Middle Tennessee State University in 2009 under the direction of Dr. Scott T. Handy. His work in the Goldsmith Lab is concerned with TAO-2 inhibitors – both their discovery and mechanisms of action. Current interests include protein-ligand binding interactions, protein structure prediction and elucidation, and rational drug design.


Haixia He

Haixia He earned a B.S. in Economics from Hebei University in China. She later got an Associate's Degree in Clinical Medicine from Hebei Medical University.  Ms. He is performing an invaluable support function by making new expression vectors and purifying proteins, and is the secret to the productivity of this lab.