We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.

Our research revolves around the common theme of cell signaling and host defense:

• Ubiquitin signaling in the NF-κB pathway
• Innate immune sensing and signaling of cytosolic nucleic acids