Publications

Publications

Ganesh L, Burstein E, Guha-Niyogi A, Louder M, Mascola J, Klomp LWJ, Wijmenga C, Duckett CS, Nabel GJ. The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature, 426: 853-857 (2003). PMID: 14685242.

Burstein E, Ganesh L, Dick RD, Brewer GJ, van De Sluis B, Wilkinson J, Lewis J, Klomp LWJ, Wijmenga C, Nabel GJ, Duckett CS. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO Journal, 23: 244-254 (2004). PMC1271669.

Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS. COMMD Proteins: A Novel Family of Structural and Functional Homologs of MURR1. Journal of Biological Chemistry, 280: 22222-22232 (2005). PMID: 15799966.

Mufti AR§, Burstein E§, Csomos RA, Graf TCF, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS. XIAP is a copper binding protein deregulated in Wilson’s disease and other copper toxicosis disorders. §Equal contributors. Molecular Cell, 21: 775-785 (2006). PMID: 16543147.

Maine GN, Mao X, Komarck CM, Burstein E. COMMD1 promotes the ubiquitination of NF-κB subunits through a Cullin containing ubiquitin ligase. EMBO Journal, 26: 459-467 (2007). PMC1783443.

Mao X, Gluck N, Maine GN, Li H, Zaidi IW, Li D, Repaka A, Mayo MW, Burstein E. GCN5 is a required co-factor for a ubiquitin ligase that targets NF-κB/RelA. Genes & Development, 23: 849-861 (2009) . PMC2666342.

Maine GN, Gluck N, Zaidi IW, Burstein E. Bimolecular Affinity Purification (BAP): Tandem affinity purification using two protein baits. Cold Spring Harbor Protocols, DOI: 10.1101/pdb.prot5318 (2009). PMC2923643.

van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E. COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion. Journal of Clinical Investigation, 120: 2119-2130 (2010). PMC2877941.

Maine GN, Zaidi IW, Li H, Basrur V, Elenitoba-Johnson K, Burstein E. A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis. Nature Protocols, 5: 1447-1459 (2010). PMID: 20671728.

Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. Copper metabolism MURR1 domain containing 1 (COMMD1) regulates Cullin-RING ligases by preventing Cullin-associated NEDD8-dissociated (CAND1) binding. Journal of Biological Chemistry, 286: 32355-32365(2011). PMC3173175.

Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E. Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. Oncogene, 31: 611-623(2012). PMC3183278.

Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E. CCDC22 deficiency in humans blunts activation of pro-inflammatory NF-kB signaling. Journal of Clinical Investigation, 123: 2244–2256 (2013). PMC3635737.

Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Raetz M, Mao X, Starokadomskyy P, Sharvit E, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Faubion W, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E. Copper Metabolism Domain-containing 1 (COMMD1) represses genes that promote inflammation and protects mice from colitis and colitis-associated cancerGastroenterology, 147: 184-195 (2014). PMC4086320.

Phillips-Krawczak CA‡, Singla A‡, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang J-S, Dai H, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, van de Sluis B, Billadeau DD§, Burstein E§.  COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.  ‡,§Equal contributors. Molecular Biology of the Cell, 26: 91-103 (2015). PMC4279232.

Li H, Koo Y, Mao X, Sifuentes-Dominguez  L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen J, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein EEndosomal sorting of Notch receptors through COMMD9 dependent pathways modulates Notch signaling.  Journal of Cell Biology, 211: 605-617 (2015). PMC4639872.

Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzweski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR§, Burstein E§.  DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis.  §Equal contributors.  Nature Immunology, 17: 495–504 (2016). PMC4836962.

Starokadomskyy P, Sifuentes-Dominguez L, Gemelli T, Zinn AR, Dossi MT, Mellado C, Bertrand P, Borzutzky A, Burstein EEvolution of skin manifestations in X-linked pigmentary reticulate disorder.  British Journal of Dermatology, In Press (2017).