Tumor Suppression by p53 Genes

We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.



We use powerful genetic tools to probe apoptotic cell death in vivo.

Cell Death

We examine gene-directed programs that specify programmed and unprogrammed cell death.

p53 Regulatory Network

The p53 gene is mutated in most human cancers. We examine the p53 network in living cells in situ.

Genomic Dark Matter

We study genomic dark matter to determine how "noncanonical" RNAs might encode meaningful content.

Meet the Lab