Tumor Suppression by p53 Genes
We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.
We examine gene-directed programs that specify programmed and unprogrammed cell death.
The p53 gene is mutated in most human cancers. We examine the p53 network in living cells in situ.
We study genomic dark matter to determine how "noncanonical" RNAs might encode meaningful content.