Our Team

James S. Malter, M.D.

James Malter

James S. Malter, MD is the Professor and Senator Betty and Dr. Andy Andujar Distinguished Chairman of Pathology. Prior to joining the University of Texas Southwestern Medical Center in 2011, he was Professor of Pathology and Lab Medicine at the University of Wisconsin-Madison and Associate Director of Biological Sciences at the Waisman Center for Intellectual Disabilities. For 20 years he also served as the Medical Director of the Blood Bank and Transfusion Services at the University of Wisconsin Hospital and Clinics. He has been a funded, National Institutes of Health Principal Investigator for the past 29 years, first on K08 and later R01, P01, P30 and P50 mechanisms. He has served on many NIH, National Science Foundation, Veterans Administration and Department of Defense review groups, including 3 years as founding Chair of the NIH Center for Scientific Review Neural Oxidative Metabolism and Death Study Section. He is currently on the editorial board of Science Signaling, and is an elected member of the American Society for Clinical Investigation. His research focuses on molecular mechanisms of gene expression and intracellular signaling principally in the brain and immune systems. Dr. Malter earned his AB from Dartmouth College and MD from Washington University prior to residency training and a post-doctoral fellowship at the University of Pennsylvania.


Shen ZJ, Malter JS. XBP1, a determinant of the eosinophil lineage. Nat Immunol. 2015

Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009

Shen ZJ, Esnault S, Malter JS. The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils. Nat Immunol. 2005