TRPM4, a calcium-activated, PI(4,5)P2-modulated, non-selective cation channel, plays important roles in many physiological processes such as insulin secretion in pancreatic β cells.

The success continues: collaborative effort by the Bai and Jiang labs results in the second Nature publication this year.

TRPM4 is a calcium-activated, PI(4,5)P2-modulated, non-selective cation channel that plays important roles in many physiological processes such as insulin secretion in pancreatic β cells and breath pace-making in brainstem neurons, and its mutations was found to be associated with human heart conduction dysfunction. The labs from Dr. Xiao-chen Bai and Dr. Youxing Jiang determined the single particle cryo-EM structures of the mouse TRPM4 channel in the apo- and ATP-bound states with 3.1 Å and 2.9 Å resolution, respectively (Guo et al. Nature, 2017).

Along with electrophysiological analysis, this study not only reveals the unique molecular architecture of the TRPM family, but also elucidates the structural basis of ATP modulation and ion selectivity of the TRPM4 channel.

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