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Awards for July 2015

Federal Awards

Abrams, John, NIH, Molecular and Genetic Control of Programmed Cell Death, $397,500; Abrams, John, NIH, Suppression of Mobile Elements by p53 Genes, $318,963; Abrams, John (Fellow A. Butler), NIH, A Model for Deconstructing p53 Function in Stem Cells, $30,811; Amatruda, James, Univ of Minnesota/NIH, Molecular Epidemiology of Pediatric Germ Cell Tumors, $12,207; Bezprozvanny, Ilya (Fellow D. Ryskamp), NIH, Synaptic Calcium Dysregulation in Huntington’s Disease, $55,190; Burstein, Ezra, NIH, Gastroenterology/Hepatology Research Training Program, $243,409; Choi, Changho, NIH, Clinical Development of Cancer-Specific MRS Biomarkers in Malignant Gliomas, $329,925; Chong, Benjamin, NIH, Molecular Markers in Discoid Lupus Erythematous, $123,012; Chopra, Rajiv, NIH, Image-Guided Doxorubicin Delivery for Pediatric Sarcomas, $554,651; Chuang, David, Baylor Col of Med/NIH, Phenylbutyrate Therapy for Maple Syrup Urine Disease, $120,460; Crandall, Craig, NIH, Exercise in Burn Survivors – Equipment Supplement, $92,600;

Cruz, Ponciano, NIH, Dermatology Research Training Program, $127,358; De Brabander, Jef, NIH, Chemical and Biological Optimization of a Gram Negative Selective Antibiotic, $238,861; Deberardinis, Ralph, Emory Univ/NIH, Signaling and Targeting of 6-Phosphogluconate Dehydrogenase in Human Cancers, $17,544; Debose-Boyd, Russell, NIH, Elucidating Role of UBIAD1 in Sterol-Accelerated ERAD of HMG CoA Reductase, $302,100; Diamond, Marc, NIH, Development of Novel Therapeutic Anti-Tau Antibodies, $593,025; Drazner, Mark H, Duke Univ/NIH, Guiding Evidence Based Therapy Using Biomarker Intensified Treatment, $5,905; Elmquist, Joel (Fellow C. Lord), NIH, Role of Serotonin Signaling in POMC Neurons to Regulate Lipid Homeostasis, $54,194; Engelking, Luke, NIH, SREBP-Mediated Lipid Regulation in the Intestine, $147,246; Gerber, David, NIH, Evaluating Prior Cancer Exclusion Policy to Increase Lung Cancer Trial Accrual, $80,750; Gibson, Jay, NIH, FMRP Regulates the Pruning of Cell-to-Cell Connections in the Neocortex, $79,500;

Greenberg, Benjamin, Univ of Cal, San Francisco/NIH, Environmental & Genetic Risk Factors for Peds MS, $14,151; Gumbo, Tawanda, NIH, Short Course Therapy for MDR-TB Based on PK/PD Answers for Biological Variability, $3,611; Gupta, Olga, NIH, Peritoneal Mesothelial Cells: Role in Obesity and Metabolic Dysfunction, $190,570; Herz, Joachim (Fellow C. Lane-Donovan), NIH, The Role of Reelin in Adult Neuronal Function and Alzheimer's Disease, $28,477; Hobbs, Helen, NIH, Role of PNPLA3 in Fatty Liver Disease, $345,825; Hsieh, Jer-Tsong, NIH, Targeting Aggressive Prostate Cancer with Novel Theranostic Nanomedicine, $326,384; Hsieh, Jer-Tsong, NIH, Developing Targeted Therapy with Prostate Cancer Specific Nanomedicine, $312,584; Huber, Kimberly, NIH, Mechanisms of mGluR Function and Dysfunction in Mouse Autism Models, $410,720; Iannaccone, Susan, Children’s Res Inst/NIH, Center for Research Translation of Systemic Exon-Skipping in Muscular Dystrophy, $24,500; Jia, Xun, NIH, 4D Cone Beam CT Reconstruction for Radiotherapy via Motion Vector Optimization, $242,250;

Jimenez, Patricia, Washington Univ in St. Louis/NIH, RDSP – miRNAs in Implantation and Decidualization – NIH, $108,001; Johnson, Jane (Fellow T. Vue), NIH, Underlying Molecular Mechanisms of Gliogenesis and Gliomagenesis, $82,184; Journeycake, Janna, UT HSC Houston/HRSA, Hemophilia Treatment Centers (SPRANS), $25,423; Kitchell, Ellen, HRSA, Ryan White Title IV Women, Infants, Children ... AIDS, $1,038,418; Kraus, William, NIH, Activity of Nuclear Receptor Coregulators with Chromatin, $396,966; Lingvay, Ildiko, Joslin Diabetes Ctr/NIH, PERL Study: Multicenter Clinical Trial of Allopurional to Prevent GR Loss in TID, $351,043; Malloy, Craig, NIH, Southwestern NMR Center for In Vivo Metabolism, $1,089,421; Malloy, Craig, Duke Univ/NIH, Development of Novel Therapies for NIDDM: Project 4, $467,792; Moreland, Jessica, NIH, A Novel Anti-Inflammatory Role for the Neutrophil NADPH Oxidase, $198,750; Morrison, Sean, NIH, Regulation of Stem Cell Aging, $316,172; Munshi, Nikhil (Fellow A. Fernandez-Perez), Natl Science Fdn, Graduate Research Fellowship Program – Fernandez-Perez, $46,000;

Nesbitt, Shawna, Minneapolis Med Res Fdn/NIH, Aspirin in Reducing the Effects on the Elderly, $44,636; Nugent, Alan, NIH, Development of Large Diameter Biodegradable Stents for Congenital Heart Disease, $226,147; Okada, Pamela, Univ of Virginia/NIH, Established Status Epilepticus Treatment Trial (ESETT), $50,000; Olson, Eric, NIH, Metabolic Control by Myogenic MicroRNAs, Mediator and Myokines, $477,000; Olson, Eric, NIH, Molecular Dissection of Myoblast Fusion In Muscle Development and Regeneration, $350,347; Olson, Eric (Fellow K. Carroll), NIH, The Role of the Myocardin-Related Transcription Factors in Cardiac Development, $54,194; Pasare, Chandrashekhar, NIH, Role of BCAP in Regulating Inflammation and Adaptive Immunity, $201,875; Petroll, Matthew, NIH, Modulation of Corneal Wound Healing Using Pre-Surgical Dietary Restriction, $240,098; Phillips, Margaret, NIH, Polyamine and Trypanothione Metabolism in Trypanosoma Brucei, $490,363; Raj, Ganesh (Fellow Y. Yin), Dept of Defense, Role of Alternative Spliced Androgen Receptor in the Radiation Response of Prostate Cancer, $119,176;

Raskin, Philip, George Washington Univ/NIH, Glycemia Reduction Approaches for Diabetes: Comparative Effectiveness (GRADE), $545,162; Roberts, Todd, NIH, Neuronal Circuit Mechanisms for Learning During Social Interactions, $282,625; Rosenberg, Roger, NIH, Neurobiology of Alzheimer's Disease and Aging, $1,657,884; Sadek, Hesham, NIH, Role of Meis1 in Regulation of Cardiomyocyte Proliferation, $504,559; Sakhaee, Khashayar, NIH, Pathogenesis of Uric Acid Nephrolithiasis: The Multifaceted Role of Renal Lipids, $357,750; Satterthwaite, Anne, NIH, Attenuation of Lupus by Foxo3, $213,180; Sawant, Amit, NIH, Personalized Motion Management for Truly 4D Lung Stereotactic Body Radiotherapy, $554,664; Schaffer, Joseph, NIH, NICHD Pelvic Floor Disorders Network Clinical Sites, $104,959; Schaffer, Joseph, RTI Intl/NIH, NICHD Pelvic Floor Disorders Network – Capitation Funding, $33,080; Scherer, Philipp, NIH, Endocrine and Metabolism Training Grant, $235,072; Scherer, Philipp, Yale Univ School of Med/NIH, Metabolic Markers and Predictors of Childhood Obesity, $27,809;

Scherer, Philipp (Fellow J. Stern), NIH, The Role of A-Cell Mitochondria in Glucagon Secretion and Glucose Homeostasis, $56,042; Shay, Jerry, Georgetown Univ/NASA, GU/NASA Core A – 410929_GR410924-UTSMC-CORE A, $8,058; Shiloh, Michael, NIH, Carbon Monoxide Resistance in Mycobacterium Tuberculosis Pathogenesis, $397,500; Souza, Rhonda, NIH, Role of Acid in Development of Barrett's Esophagus, $274,050; Strand, Douglas, NIH, Mechanisms of Fatty Acid Metabolism in Prostate Differentiation and Disease, $137,484; Tamminga, Carol, Mount Sinai School of Med/NIH, Epigenetic Mechanisms of Depression, $159,000; Towler, Dwight, NIH, Endocrine Regulation of Calcific Aortic Valve Sclerosis: PTH/PTHRP Receptor Signa, $397,693; Trivedi, Madhukar, NIH, Clinical Trials Network: The Texas Node, $800,475; Tsai, Peter, NIH, Mechanisms Underlying the Cerebellar Contribution to Autism, $190,458; Wang, Richard, NIH, Elucidating Role of Akt and Keratins in Autophagy and Tumorigenesis, $143,312;

Wang, Zhigao (Fellow E. Reynoso), NIH, Biochemical Dissection of the Execution Step of Mammalian Necrotic Cell Death, $30,703; Wolf, Matthias, NIH, Role of Uromodulin in Regulation of Renal Calcium Channel TRPV5, $145,331; Wyckoff, Myra, RTI Intl/NIH, NICHD Neonatal Research Network Capitation Funding, $47,369; Wyckoff, Myra, Wayne State Univ/NIH, Cooperative Multicenter Network of Neonatal Intensive Care Units, $10,558; Xiao, Guanghua, NIH, Integrative Analysis to Identify Therapeutic Targets for Lung Cancer, $329,925; Xie, Yang, Leidos Biomedical Res Inc/NIH, S15-82 NCI-DREAM Challenge Proposal Request Package, $99,901; Ye, Jin, NIH, Proteolytic Activation of CREB3L1 in Treating Cancers and Tissue Fibrosis, $403,750; Zechner, Christoph, NIH, The Role of FGF15/19 – y Klotho FGFR Axis in Renal Phosphate Homeostasis, $150,972; Zhu, Hao, NIH, Metabolic Roles for Lin28-let-7 miRNA Pathway in Sarcoma Tumorigenesis, $135,648; Zigman, Jeffrey, NIH, Mechanisms of Ghrelin Secretion, $363,375.

Nonfederal Awards

Ahn, Chul, CPRIT, C1: Biostatistics, $119,261; Amatruda, James (Fellow G. Kendall), Amer Assoc for Cancer Res, Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma, $50,000; Aubert, Virginie, Amer Heart Assoc Natl, Receptor Trafficking Regulation in Hypothalamic Neurons:  A Mechanism Underlying Obesity and Associated Diseases, $77,000; Boothman, David, Pancreatic Cancer Action Network, Use of PARP1 Inhibitors to Leverage a Tumor-Selective “Kiss of Death”, $150,000; Boothman, David, Amer Assoc for Cancer Res, Exploiting an NQO1 "Kiss of Death" for Pancreatic Cancer Therapy, $125,000; Brekken, Rolf, Univ of Houston/CPRIT, Tumor Cell Lytic Peptoids that Target Exposed Phosphatidylserine, $56,043; Brenner, Adam (Fellow J. Moore), Amer Psychiatric Assoc, SAMHSA Minority Fellowship Program, $12,048; Brion, Luc, Gerber Fdn, Individualizing and Optimizing Nutrition to Prevent Metabolic Syndrome and to Improve Neurodevelopment in Preterm and Small for Gestational Age Infants, $105,787;

Chen, Benjamin, UT Arlington/CPRIT, C2; Live Cell Imaging Core, $54,050; Chen, David, CPRIT, P1: Impact of DNA-PKcs Phosphorylation at T2609 Cluster on Pathway Choice for DNA Double-Strand Break Repair and Tumorigenesis – P1, $296,182; Chen, David, CPRIT, AC: DNA Double-Strand Break Repair and Genome Stability, $104,766; Conrad, Nicholas, Amer Cancer Soc, Posttranscriptional Regulation of Metabolic Genes Involved in Cancer, $198,000; Deberardinis, Ralph (Fellow J. Kim), Amer Lung Assoc, ALA Kim Fellowship, $32,500; Diamond, Marc, Harrington Discovery Inst, Harrington Scholar-Innovator Award, $20,990; Gao, Fan, Amer Orthotic and Prosthetic Assoc, Vacuum Assisted Socket System, $15,000; Glass, Donald, Dermatology Fdn, Determining the Genetic Causes of Keloid Formation, $55,000; Goldsmith, Elizabeth, Amer Heart Assoc SW, Inhibitors of the Hypertension Drug Target WNK1, $70,000;

Graff, Jonathan (Fellow R. Ugrankar), Amer Diabetes Assoc, Characterization of Novel Genetic Factors of Hyperglycemia Identified in Drosophila Melanogaster through Partial Genome Screen, $42,750; Greilich, Philip, UT System, Enhancing Communication for Handovers from the Operating Room to the ICU (ECHO-ICU), $46,851; Henne, William, Amer Fed for Aging Res, Novel ER-Lysosome Inter-Organelle Tethers in Lipid Metabolism and Aging, $49,250; Hill, Joseph, CPRIT, P3: Maladaptive Cardiomyocyte Autophagy as Mechanism of Doxorubicin-Induced Heart Failure, $300,000; Hill, Joseph (Fellow D. Li), Amer Heart Assoc SW, Doxorubicin-Induced Suppression of Autophagic Flux as a Mechanism of Cardiotoxicity, $25,000; Hooper, Lora (Fellow S. Bel), EGL Charitable Fdn, The Role of BCL2 in Regulating Antibacterial Autophagy in the Intestinal Epithelium, $76,680; Horton, Jay, Fondation Leducq, Triglyceride Metabolism in Obesity and Cardiovascular Disease, $99,000; Jain, Raksha, Cystic Fibrosis Fdn, Cystic Fibrosis Foundation Care Center Grant, $113,230;

Jimenez, Patricia, Washington Univ St. Louis/Burroughs Wellcome, RDSP – miRNAs in Implantation and Decidualization – BWF, $25,000; Kim, James, Sidney Kimmel Fdn, The Interaction of Stromal Hedgehog Pathway with Cancer Stem Cells of Lung Adenocarcinoma, $100,000; Kumbhani, Dharam, Amer Col of Cardiology, High-Dose vs. Low-Dose Statin Therapy for Lower Extremity Plaque Regression, $70,000; Lacritz, Laura, UT System, Jess Hay Endowment Award for Daniel Brown, $10,000; Levine, Beth (Fellow Y. Liu), Amer Heart Assoc SW, The Role of Autosis in Ischemia-Induced Cell Death, $51,092; Liu, Ning, Amer Heart Assoc SW, Role of Twist-2 Positive Progenitor Cells in Adult Heart Regeneration, $70,000; Liu, Tiemin, Amer Heart Assoc Natl, Autonomic Regulation of Adipocyte Metabolism by Melanocortin-4 Receptors, $77,000; Mason, Ralph, CPRIT, C1: In Vivo Imaging Core, $186,077;

McKnight, Steven, CPRIT, AC: Discovery of New Drugs for Treatment of Lung Cancer, $138,438; Mendell, Joshua, CPRIT, Recruitment of Rising Stars, $900,000; Minna, John, CPRIT, P1: Molecular Biomarker ID, $423,843; Minshall, Christian, TX Higher Educ Coord Bd, Emergency and Trauma Care Education Partnership Program, $31,700; Nijhawan, Deepak, Damon Runyon Cancer Res Fdn, Using Chemistry to Identify New Targets in Lung Cancer, $150,000; Noe, Carl, Boston Scientific Neuromodulation, UT Southwestern Pain Medicine Fellowship, $15,000; O'Donnell-Mendell, Kathryn, Sidney Kimmel Fdn, Dissecting Novel Mechanisms of Lung Cancer Pathogenesis, $100,000; Olson, Eric, CPRIT, P2: MicroRNA Mechanisms and Therapies to Protect Heart During Cancer Chemotherapy, $300,000; Oltmann, Sarah, Amer Thyroid Assoc, Cancer Progression and Therapeutic Response in a Mouse Model of Medullary Thyroid, $28,750;

Posner, Bruce, CPRIT, C2: HTS Core, $419,531; Raj, Ganesh, UT HSC San Antonio/CPRIT, ESR1 Coregulator Binding Site Inhibitors (ECBIs) as Novel Therapeutics to Target Hormone Therapy Resistant Metastatic Breast Cancer, $263,158; Raj, Ganesh (Fellow S. Ma), Amer Urological Assoc, QevOS, a Novel Quantitative Model System for Prostate Cancer Bone Metastases, $40,000; Ready, Joseph, CPRIT, P3: Chemistry, $399,830; Repa, Joyce, Amer Diabetes Assoc, Vitamin D Receptor and Islet Biology, $115,000; Rubin, Craig, Donald W. Reynolds Fdn, UT Southwestern Aging and Geriatrics Education (SAGE) Next Steps Program, $250,000; Rutkowski, Joseph, Amer Heart Assoc Natl, Lymphatic Circulation: Regulator of Adipose Tissue Metabolism, $77,000; Scaglioni, Pier, TX 4000, Cancer Research Grant Texas 4000, $50,000; Schneider, Jay, CPRIT, P5: Coronary Microvasculature as Target for Cardioprotection for Cancer-Therapy Induced Heart Failure, $265,677; Schneider, Jay, CPRIT, Administrative Core: Cardiotoxicity of Cancer Chemotherapy: Novel Mechanisms and Therapeutic Strategies, $78,168;

Schoggins, John, Rita Allen Fdn, Interferon-Mediated Modulation of Cellular Metabolism as Antiviral Strategy, $110,000; Sharma, Preeti, Cystic Fibrosis Fdn, Cystic Fibrosis Care, Teaching and Research Center, $134,180; Sher, David, Radiation Oncology Inst, Comparative Value of Transoral Surgery and Radiation for Oropharynx Cancer, $190,710; Sherry, Dean (Fellow C. Preihs), Amer Diabetes Assoc, In Vivo Imaging of Beta Cell Function with Zinc Responsive Contrast, $40,500; Sun, Xiankai, CPRIT, Acquisition of Biomedical Cyclotron and Development of Comprehensive Positron Emission Tomography Program at UT Southwestern for Cancer Research, $300,000; Tsai, Shirling, Amer Surgical Fdn, Control of TGF-beta Signaling by LRP1 in the Pathogenesis of Aortic Aneurysms, $75,000; White, Michael, CPRIT, P2: Compound Target ID; Discovery of New Drugs for Treatment of Lung Cancer, $569,083; White, Michael, CPRIT, P3: Mapping Landscape of Conditional Vulnerabilities in Ovarian Cancer, $296,187; Williams, Noelle, CPRIT, C3: Pharmacology Core, $256,500;

Wu, Jiang, Amer Cancer Soc, Epigenetic Regulation of Mammalian Sonic Hedgehog Signaling Pathway, $180,000; Yu, Hongtao, CPRIT, P3: Regulation of DNA Repair Pathway Choice by Cohesin and Smc5/6 Complex, $296,186; Zhang, Chengcheng, Leukemia & Lymphoma Soc, Role of Angptl Receptor in Acute Myeloid Leukemia, $110,000; Zhang, Rong (Fellow T. Tarumi), Amer Heart Assoc SW, Arterial Stiffness, Intracranial Hemodynamics and Leukoaraiosis, $49,340; Zigman, Jeffrey (Fellow B. Mani), Davis Fdn, Mechanisms Regulating Ghrelin Secretion during Chronic Caloric Restriction, $51,000.

Industry Sponsored Awards

(Dollar amounts not available)

Chopra, Rajiv, Exploration of Methods for MRI-Guided Interventions at 3T, Profound Medical; Diercks, Deborah, Tbit Evaluation Study, BioDirection; Frankel, Arthur, Phase 2 Trial of Talimogene Laherparepvec Neoadjuvant Treatment Plus Surgery vs. Surgery Alone, Amgen; Frankel, Arthur, Phase 3b Study of Talimogene Laherparepvec for Unresected, Stage IIIB to IVM1a Melanoma, Amgen; Iannaccone, Susan, Phase 3 Study of ISIS 396443 Intrathecally in Pts with Later-Onset Spinal Muscular Atrophy, INC Res/ISIS Pharma; Jain, Mamta, Phase 3 Study of BMS-663068 in Heavily Treated Sbjs with Multi-Drug Resistant HIV-1, Bristol-Myers Squibb; Jain, Mamta, Phase 3 Study of D/C/F/TAF Once-Daily vs. bPI with FTC/TDF in HIV-1 Subjects, Janssen Res & Dev; Jain, Raksha, Phase 3 Study of Ivacaftor and VX-661 with Ivacaftor in Sbjs 12 Yrs+ with Cystic Fibrosis, Greenphire Inc/Vertex Pharma;

Laetsch, Theodore, Phase 1 Trial of Temsirolimus (CCI-779, Pfizer Inc.) with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma, Children’s Hosp of Los Angeles/Pfizer; Magadan, Alejandro, Phase 3 Study of Reversal of Anticoagulant Effects of Dabigatran by IV Administration of 5.0g Idarucizumab, Boehringer Ingelheim Pharma; Rodriguez-Baez, Norberto, Phase 2 Study of Ledipasvir/Sofosbuvir +/- Ribavirin in Adolesc and Children with Chronic HCV-Infection, Gilead Sciences; Torres, Fernando, Extension Study of APD811-003 in Pts with Pulmonary Arterial Hypertension, Arena Pharma; Torres, Fernando, Phase 2 Trial of APD811 in Pts with Pulmonary Arterial Hypertension, Arena Pharma; Wilkie, Thomas, Biliary Tree Stem Cell Migration from Hepatic and Pancreatic Ducts Toward the Liver and/or Pancreas During Tissue Repair, Vesta Therapeutics.