Research

Research

Dysregulation of the body's complex energy balance causes various metabolic diseases, including obesity, diabetes, and non-alcoholic fatty liver diseases.

In the Zhang lab, we seek to understand the key molecular mechanisms to maintain energy balance in our body, with the long-term goal of creating novel therapeutic strategies.

Our investigation began with a search for mutations that cause metabolic disorders in mice, using the largest mouse forward genetic screen platform in the Center for the Genetics of Host Defense. We have screened half the mouse genome, and now study the role of these targeted genes in metabolic regulation.