Cardiac Autophagy in Sepsis

Autophagy, a lysosome-dependent process of removing damaged proteins and organelles, is stimulated during sepsis.

We recently detected a significant accumulation of autophagosomes in the heart tissue of septic animals; this change was alleviated by mitochondria-targeted vitamin E (Mito-Vit-E).

Our ongoing work aims to identify the molecular pathways of mtROS-dependent autophagy and to determine the pathological role of autophagy in sepsis outcomes using both in vitro and in vivo models.

Electron microscopy images
mtROS-dependent autophagosome formation in myocardium of septic rats