Featured Publications

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-kB pathway

Shahanshah Khan, Mahnoush S. Shafiei, Christopher Longoria, John Schoggins, Rashmin C. Savani, Hasan Zaki BioRxiv 2021

The AIM2 and NLRP3 inflammasomes coordinately mediate the effect of radiation by facilitating IL-1 signaling in dendritic cells

Chuanhui Han, Victoria Godfrey, Zhida Liu, Yanfei Han, Longchao Liu, Hua Peng, Ralph W, Weichselbaum, Hasan Zaki*, Yang-Xin Fu*. * co-correspondence Science Immunology 2021 6 59

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A Ramachandran, Brandi L. Cantarel, Cassie Behrendt, Lan Peng, Lora V. Hooper, and Hasan Zaki Science Translational Medicine 2020

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

SM Nashir Udden, Youn-tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Md Hasan Zaki eLIFE 2019

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.

Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.

Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60

The Nlrp3 inflammasome: contributions to intestinal homeostasis.

Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91