Featured Publications

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A Ramachandran, Brandi L. Cantarel, Cassie Behrendt, Lan Peng, Lora V. Hooper, and Hasan Zaki Science Translational Medicine 2020

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

SM Nashir Udden, Youn-tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Md Hasan Zaki eLIFE 2019

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.

Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.

Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60

The Nlrp3 inflammasome: contributions to intestinal homeostasis.

Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91

Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.

Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35

Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma.

Khan S, Zaki H, Int J Mol Sci 2020 Jan 21 2