Research

Metabolism and its Role in Retinal Degeneration

The Wert laboratory is interested in studying the metabolism of the retina and the metabolic dysregulation that occurs during the progression of retinal degenerative disease. In particular, the laboratory focuses on metabolic rescue and reprogramming as a method of neuroprotection for the photoreceptor cells of the retina, and a potential therapeutic approach to treat patients with retinal dystrophies regardless of their genetic mutation.

  • Wert KJ*, Velez G*, Vijayalaksmi K, Shankar V, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB. (2020) Metabolite therapy guided by liquid biopsy proteomics delays retinal degeneration. EBioMedicine 52:102636. *These authors contributed equally to this work.
  • Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany J, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB. (2018) Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface. Free Radic Biol Med 124:408-419.