Research

Animal Models of Ocular Disease

The Wert laboratory specializes in the creation of animal models of ocular disease, to study the mechanisms underlying the disease and test potential therapeutic agents.

  • Wert KJ, Bassuk AG, Wu WH, Coglan D, Wu S, Yang J, Gakhar L, Tsang SH, Mahajan VB. (2015) The R234L mutation in CAPN5 increases calpain catalytic activity and triggers intraocular inflammation in a mouse model of hereditary uveitis. Hum Mol Genet 24:4584-4598.
  • Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Hsu CW, Tosi J, Nagasaki T, Janisch KM, Kasanuki JM, Grant MB, Mahajan M, Bassuk A, Tsang SH. (2016) Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy. Signal Transduct Target Ther 1: pii: 16005.
  • Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB. (2019) CAPN5 inactivation phenotype supports therapeutic inhibition trials. Hum Mutat. 40(12):2377-2392.