Disease Models for Inherited Ocular Disease
The Wert laboratory uses cutting-edge technologies in translational studies to bridge the bench to the bedside. We focus on inherited genetic mutations that act as disease-causing alleles for retinal degenerative disorders. We model these complex human diseases using both genetically engineered mice as well as human cell lines, including embryonic and induced pluripotent stem cells.
Therapeutics for Ocular Disease
The long-term goal of the Wert laboratory is to discover and understand the genetic mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.