Necroptosis is a highly pro-inflammatory form of programmed necrotic cell death, morphologically characterized by organelle swelling and plasma membrane rupture. Recent studies have implicated necroptosis in a broad range of pathological conditions including infection, inflammation, ischemia injury, neurodegeneration and cancer. Understanding the regulation of necroptosis will have profound impact on human health. The long-term goal of my lab is to understand the molecular mechanisms of the necroptosis pathway and develop chemical compounds that will help treat necroptosis-associated diseases. My lab will investigate the mechanisms of necroptosis, using a combination of chemical biology, biochemistry and genetics approaches.