Publications for Zhao Wang, Ph.D.

Wang Z, Ying K, Lin S, Wu H, Xie Y and Mao Y. Molecular cloning and characterization of a novel full-length cDNA encoding zinc finger protein of KRAB type. Hereditas (Beijing) 2000; 22(4): 247-251.

Lin S, Fang X, Ying K, Jin H, Wang Z, Xie Y and Mao Y. Molecular cloning of a new member of human RNA helicase family. J. of Fudan University (Natural Science) 2001; 39(6): 645-650.

Chen X, Sun Z, Wang Z, Yang Q, Ying K, Xie Y and Mao Y. Cloning, sequencing and expression of a novel cDNA coding for human homolog of Rab protein. J. of Fudan University (Natural Science) 2001; 39(6): 688-691.

Lin S, McLennan AG, Ying K, Wang Z, Gu S, Jin H, Wu C, Liu W, Yuan Y, Tang R, Xie Y and Mao Y. Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA Gene. J. Biol. Chem. 2001; 276: 18695-18701.

Yang QS, Ying K, Yuan HL, Chen JZ, Meng XF, Wang Z, Xie Y and Mao YM. Cloning and expression of a novel human Galectin cDNA, predominantly expressed in placenta. Biochim. Biophys. Acta. 2001; 1574: 407-411.

Lin S, Gasmi L, Xie Y, Ying K, Gu S, Wang Z, Jin H, Cao Y, Wu C, Zhou Z, Tang R, Mao Y and McLennan AG. Cloning, expression and characterization of a human nudix hydrolase specific for adenosine 5’-diphosphoribose (ADP-ribose). Biochim. Biophys. Acta. 2002; 1594: 127-135.

Deng Y, Wang Z, Ying K, Gu S, Ji C, Huang Y, Gu X, Wang Y, Xu Y, Xie Y and Mao Y. NADPH-dependent GMP reductase isoenzyme of human (GMPR2): EXPRESSION, PURIFICATION, AND KINETIC PROPERTIES. Int. J. Biochem. Cell Biol. 2002; 34: 1035-1050.

Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y and Mao Y. Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1). DNA Sequence 2002; 13(5): 301-306.

Corvera S, Burkart A, Kim JY, Christianson J, Wang Z and Scherer PE. Keystone meeting summary: ‘Adipogenesis, obesity, and inflammation’ and ‘Diabetes mellitus and the control of cellular energy metabolism,’ January 21–26, 2006, Vancouver, Canada. Genes and Develop. 2006; 20(16): 2193-2201.

Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A and Scherer PE. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol. Cell Biol. 2007; 27(10): 3716-3731.

Wang ZV and Scherer PE. DsbA-L is a versatile player in adiponectin secretion. Proc. Natl. Acad. Sci. USA. 2008; 105(47):18077-18078.

Schraw T, Wang ZV, Halberg N, Hawkins M and Scherer PE. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology 2008; 149(5): 2270-2282.

Wang ZV and Scherer PE. Adiponectin, cardiovascular function and hypertension. Hypertension 2008; 51(1): 8-14.

Wang ZV, Mu J, Schraw TD, Gautron L, Elmquist JK, Zhang BB, Brownlee M and Scherer PE. PANIC-ATTAC, an inducible and reversible mouse model for beta cell ablation. Diabetes 2008; 57(8):2137-2148.

Yu X, Park BY, Wang MY, Wang ZV and Unger RH. Making insulin-deficient type I diabetic rodents thrive without insulin. Proc. Natl. Acad. Sci. USA. 2008; 105(37):14070-14075.

Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S and Scherer PE. Metabolic dysregulation and adipose tissue fibrosis: The role of Collagen VI. Mol. Cell Biol. 2009; 29(6):1575-1591.

Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA and Scherer PE. HIF1 alpha induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell Biol. 2009; 29(16): 4467-4483.

Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J, Hamilton MP, Luby-Phelps K and Scherer PE. Systemic fate of adipocyte-derived factor adiponectin. Diabetes 2009; 58(9):1961-1970.

Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD and Kaestner KH. The transcriptional response of the beta cell to pregnancy in mice. Mol. Endocrinol. 2009; 23(10):1702-1712.

Wang ZV, Rothermel BA and Hill JA. Autophagy in hypertensive heart disease. J. Biol. Chem. 2010; 285(12):8509-8514.

Battiprolu PK, Gillette TG, Wang ZV, Lavandero S and Hill JA. Diabetic cardiomyopathy: mechanisms and therapeutic targets. Drug Discov. Today Dis. Models. 2010; 7(2):e135-143.

Wang ZV, Deng Y, Wang QA, Sun K and Scherer PE. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 2010; 151(6):2933-2939.

Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O and Wilkie TM. Rgs16 and Rgs8 expression in embryonic endocrine pancreas and mouse models of diabetes. Dis. Model. and Mech. 2010; 3:567-580.

Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA and Scherer PE. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 2011; 17(1):55-63.

Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales C, Kong Y, Rothermel BA, Gillette TG and Hill JA. HDAC inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc. Natl. Acad. Sci. USA. 2011; 108(10):4123-4128.

Chiong M*, Wang ZV*, Pedrozo Z, Cao DJ, Troncoso R, Criollo A, NemChenko A, Hill JA and Lavandero S. Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis. 2011; 2:e244. (*, equal contributions)

Luo X, Jiang N, Hojayev B, Wang ZV, Tandan S, Rakalin A, Rothermel BA, Gillette, TG and Hill JA. STIM1-dependent store-operated Calcium entry is required for pathological cardiac hypertrophy. J. Mol. Cell. Cardiol. 2012; 52(1):136-147.

Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S and Hill JA. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy. J. Clin. Invest. 2012; 122(3):1109-1118.

Sun K, Asterholm IW, Kusminski CK, Bueno AC, Wang ZV, Pollard JW, Brekken RA and Scherer PE. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc. Natl. Acad. Sci. USA. 2012; 109(15):5874-5879.

Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman M, Hill JA, Horton JD and Scherer PE. The Xbp1s-GalE axis links ER stress to postprandial hepatic metabolism. J. Clin. Invest. 2013; 123(1):455-468.

Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF and Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int. Rev. Cell Mol. Biol. 2013; 301:215-290.

Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC, Moe OW, Susztak K and Scherer PE. Adiponectin promotes functional recovery after podocytes ablation. J. Am. Soc. Nephrol. 2013; 24(2):268-282.

Wang ZV, Ferdous A and Hill JA. Cardiomyocyte autophagy: metabolic profit and loss. Heart Fail. Rev. 2013; 18(5):585-594.

Battiprolu PK, Lopez-Crisosto C, Wang ZV, Nemchenko A, Lavandero S and Hill JA. Diabetic cardiomyopathy and metabolic remodeling of the heart. Life Sci. 2013; 92(11):609-615.

Davis KE, Neinast MD, Sun K, Skiles WM, Bills JD, Zehr JA, Zeve D, Hahner LD, Cox DW, Gent LM, Xu Y, Wang ZV, Khan SA and Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol. Metab. 2013; 2(3): 227-242

Li L, Wang ZV, Hill JA and Lin F. New autophagy reporter mice reveal dynamics of proximal tubular autophagy. J. Am. Soc. Nephrol. 2014; 25(2):305-315.

Zhu H, Guariglia S, Li W, Brancho D, Wang ZV, Scherer PE and Chow CW. Role of extracellular signal-regulated kinase 5 in adipocyte signaling. J. Biol. Chem. 2014; 289(9):6311-6322.

Lin F, Wang ZV and Hill HA. Seeing is believing: Dynamic changes in renal epithelial cell autophagy during injury and repair. Autophagy 2014; 10(4): 691-693.

Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK and Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 2014; 57(6): 1209-1218.

Wang ZV, Deng Y, Gao N, Zully P, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette, TG, Scherer PE and Hill JA. Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Cell 2014; 156(6):1179-1192.

Commented in:
Cell, 2014: 156(6): 1125-1127.
Nature Review Molecular Cell Biology, 2014; 15(295).
Science Signaling, 2014; 7(319): ec83.
Circulation Research, 2014; 115(6): 546-548.

Xie M, Kong Y, Tan W, May H, Battiprolu PK, Pedrozo Z, Wang ZV, Morals CR, Luo X, Cho G, Jiang N, Jessen ME, Warner JJ, Lavandero S, Gillette TG, Turer AT and Hill JA. HDAC inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. Circulation 2014; 129(10):1139-1151.

Wernstedt Asterholm I, Tao C, Morley TS, Wang QA, Delgado-Lopez F, Wang ZV and Scherer PE. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 2014; 20(1):103-118.

Wang ZV, Li DL and Hill JA. Heart failure and loss of metabolic control. J. Cardiovasc. Pharmacol. 2014;: 302-313.

Kwartler CS, Chen J, Thakur D, Li S, Baskin K, Wang S, Wang ZV, Walker L, Hill JA, Epstein HF, Taegtmeyer H and Milewicz DM. Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament associated proteins in vascular smooth muscle cells. J. Biol. Chem. 2014; 289(20):14075-14088.

Wang ZV and Hill JA. Protein quality control and metabolism: bidirectional control in the heart. Cell Metab. 2015; 21(2): 215-226.

Wang ZV and Hill JA. Diabetic Cardiomyopathy: catabolism driving metabolism. Circulation 2015; 131(9):771-773.

Altamirano F, Wang ZV and Hill JA. Cardioprotection in ischemia-reperfusion injury: novel mechanisms and clinical translation. J Physiol. In press.

Kusminski CM, Gallardo-Montejano VI, Wang ZV, Hegde V, Bickel PE, Dhurandhar NV and Scherer PE. E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte. Mol. Metab. 2015. In press.

Book Chapters

Battiprolu PK, Wang ZV and Hill JA. Chapter 24: Diabetic cardiomyopathy: potential mediators and mechanisms. In: McGuire. Editor. Diabetes in Cardiovascular Disease.