Polyomaviruses in infectious and neoplastic skin disease

Polyomaviruses mediate some of the most prevalent and persistent infections worldwide. Despite their widespread prevalence, relatively little is known about the biology and consequences of chronic polyomavirus infections.

Four of the 13 known human polyomaviruses appear to reside chronically in human skin. We have made novel disease associations with several “cutaneous” polyomaviruses and are leveraging these novel links to determine whether polyomaviruses contribute causally to disease pathogenesis.