About Us

Meet the PI

Sarah Sinnett, Ph.D.

Sarah Sinnett, Ph.D.
Assistant Professor
Child Neurology

Dr. Sarah Sinnett received a B.S. degree in Chemistry from Massachusetts Institute of Technology. She completed her graduate work under the mentorship of Dr. Jay Brenman at UNC Chapel Hill where she earned a Ph.D. in Neurobiology.

Dr. Sinnett’s post-doctoral training focused on preclinical gene therapy approaches for treating Rett syndrome, a rare neurodevelopmental disorder. She began this work at UNC in Dr. Steven Gray’s lab, then moved to UT Southwestern where she joined as faculty in 2019 in the Department of Pediatrics, Division of Pediatric Neurology. The ongoing research from the Sinnett lab has resulted in a potential candidate for the treatment of Rett syndrome in humans.

The Sinnett lab continues to explore the use of viral vectors to treat various CNS disorders and seeks to develop viral genome regulatory elements that minimize toxicity while optimizing efficacy.