A role for cGAS in tuberculosis infection

In a collaboration between the Shiloh Lab and the Chen Lab at UTSW, we found that the enzyme cGAS is vital for detection of intracellular M. tuberculosis. Importantly, cGAS was first discovered by the Chen lab in 2012. The key findings of the new paper are that cGAS is found in human tuberculosis lesions and cGAS is induced by M. tuberculosis infection. cGAS is essential for activating macrophages to produce interferons and activate autophagy, and cGAS deficient macrophages and mice are more susceptible to tuberculosis. A news release from UTSW delves deeper into the discovery, and the primary paper can be found here.