B-Cell Inhibition Pathways

Several molecules with known inhibitory function in other cell types are expressed in B cells, but their roles in B cell development and activation are poorly understood. These include inhibitory receptors as well as regulators and targets of the PI3K pathway. We are using both gain and loss-of-function approaches to assess the roles of such molecules in B cell development, the induction of B cell tolerance, and B cell activation and differentiation.