Publications for Dr. Arun Radhakrishnan

  1. Gay, A., Rye, D., and Radhakrishnan, A. (2015). Switch-like responses of two cholesterol-sensing bacterial toxins do not require protein oligomerization in membranes. Biophys. J. (in press).
  2. Das, A., Brown, M.S., Anderson, D.D., Goldstein, J.L., and Radhakrishnan, A. (2014). Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. eLife 2014; 3:e02882.
  3. Das, A., Goldstein, J.L., Anderson, D.D., Brown, M.S., and Radhakrishnan, A. (2013). Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. PNAS 110: 10580-10585.
  4. Sokolov, A., and Radhakrishnan, A. (2010). Accessibility of cholesterol in endoplasmic reticulum membranes and activation of SREBP-2 switch abruptly at a common cholesterol threshold. J. Biol. Chem. 285: 29480-29490.
  5. Radhakrishnan, A. 2010. Phase separations in binary and ternary cholesterol-phospholipid mixtures. Biophys. J. 98: L41-L43.
  6. Radhakrishnan, A., Brown, M.S., McDonald, J.G., and Goldstein, J.L. 2008. Cooperative control of SREBP-2 activation creates switch-like regulatory response to changes in ER cholesterol. Cell Metabolism 8: 512-521.
  7. Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S. 2008. Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075.
  8. Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J., Brown, M.S., and Goldstein, J.L. 2008. Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052-1063.
  9. Radhakrishnan, A., Ikeda, Y., Kwon, H.J., Brown, M.S., and Goldstein, J.L. 2007. Sterol-regulated transport from endoplasmic reticulum to Golgi: I. Oxysterols block transport by binding to Insigs. PNAS 104: 6511-6518.
  10. McConnell H. and Radhakrishnan, A. 2006. Theory of the deuterium NMR of sterol-phospholipid membranes. PNAS 103: 1184-1189.
  11. Radhakrishnan, A. and McConnell H. 2005. Condensed complexes in vesicles containing cholesterol and phospholipids. PNAS 102: 12662-12666.
  12. Radhakrishnan, A., Sun, L., Kwon, H.J., Brown, M.S., and Goldstein, J.L., 2004. Direct binding of cholesterol to the purified membrane region of SCAP: Mechanism for a sterol-sensing domain. Mol. Cell 15: 259-268.
  13. McConnell, H.M., and Radhakrishnan, A., 2003. Condensed complexes of cholesterol and phospholipid. BBA Reviews 1610: 159-173.
  14. Radhakrishnan, A., and McConnell, H.M., 2000. Chemical activity of cholesterol in membranes. Biochemistry 39: 8119-8124.
  15. Radhakrishnan, A., and McConnell, H.M., 1999. Condensed complexes of cholesterol and phospholipids. Biophys. J. 77: 1507-1517.
  16. Radhakrishnan, A., and McConnell, H.M., 1999. Cholesterol-phospholipid complexes in membranes. J. Am. Chem. Soc. 121: 486-487.