Research

Research

Dr. Petroll's laboratory applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students and post-docs. The main focus of Dr. Petroll’s research is cell mechanics and tissue engineering, in which multidimensional time-lapse imaging is used to investigate how the mechanical behavior of corneal fibroblasts is regulated by both biochemical and biophysical stimuli. He also has a longstanding interest in the development and application of in vivo confocal microscopy and in situ multiphoton imaging, which allow quantitative 3-D assessment of cell differentiation and extracellular matrix organization during corneal wound healing in response to clinical procedures such as refractive surgery or UV cross-linking.