One of Dr. Lenkinski’s major research interests is in clinical applications of in vivo Magnetic Resonance Imaging and Spectroscopy. He is also developing in vivo multinuclear MRI methods, primarily Na-23. A more recent area of interest has been molecular imaging, which involves the development of novel MR and optical-based imaging contrast.
Dr. Madhuranthakam’s research interests focus on the development of novel techniques to improve the clinical utility of MRI. His laboratory specializes in understanding and applying MR physics to exploit the variations in human anatomy and physiology to develop these novel techniques. A primary area of research involves non-contrast perfusion imaging using arterial spin labeling (ASL) applied to brain, kidneys and lungs. Another area of research includes structural and ventilation imaging of the lungs using ultrashort echo time (UTE) and whole body MRI techniques for cancer screening and staging. He works closely with radiologists in evaluating and translating these novel techniques rapidly into clinical practice.
Dr. Chopra’s research is concentrated on the development of image-guided therapies, with a focus on the biomedical applications of HIFU (High-Intensity Focused Ultrasound). Ultrasound is an attractive form of energy for therapeutic use since it can be transmitted through the body from external transducers, can be focused to very localized regions of a few mm, and can be generated from devices of multiple geometries ranging from large focused transducers to catheter based devices. A unique set of capabilities arises when this technology is combined with magnetic resonance imaging (MRI). The ultrasound technology is able to non-invasively deliver energy within the body for applications such as mild heating or tissue ablation, and MRI is able to acquire images of the temperature distribution in the heated tissues during heating. Since the relationship between temperature, time and cell kill is well established, this creates a powerful closed loop method for treating soft tissues.
The other emerging application of HIFU is to potentiate or enable targeted delivery of agents within the body. Ultrasound can be used to trigger release from temperature sensitive liposomes, or to non-invasively open the blood brain barrier. These capabilities open up many possibilities for targeted drug delivery in the brain and other organs with pre-existing vascular barriers (retina, testicles, placenta, etc).
Dr. Chopra’s research program is comprised of a preclinical component focused on novel applications of HIFU, and a translational component aimed at evaluating established HIFU approaches in patients.
Interests: Diffusion Weighted Imaging (DWI), MR Spectroscopy, MR coil design, Multinuclear MR
Research: Dr. Hulsey's research focuses on the development of quantitative Magnetic Resonance techniques. A major portion of this effort is directed toward developing quantitative measures of Diffusion Weighted Images for cancer detection and assessment of treatment response. He is also involved in the quantification of fat fraction in various organs using MR Spectroscopy. Another area of his research is directed toward radio frequency (rf) coil design. This includes building and modeling coils for multinuclear imaging and spectroscopy as well as testing coils for high field proton imaging.
Interests-Research: Prostate and renal mass MR imaging, auto/semi-automatic imaging segmentation, biostatistics. Dr. Xi's main interest focuses on developing spatially modified algorithms for image segmentation for both lesion identification and intratumoral heterogeneity analysis. He also works closely with researches in clinical studies as a biostatistian where he provides consultations on study designs and participates in data analyses.