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Publications

Conference Abstracts

  1. E. Zhang-Velten, J. Sharma, X. Wang, J. Ma, J. Chen, G. Schiattarella, J. Hill, J. M. Park, C. Malloy, V. Zaha, P. Alluri. Early in vivo detection of radiation-induced cardiotoxicity with hyperpolarized C-13 pyruvate magnetic resonance spectroscopy. American Society for Radiation Oncology. October 2021. Submitted. 
  2. J. Chen, J. Ma, C. Harrison, J. Ratnakar, Z. Zun, J. Liticker, G. Reed, A. Chhabra, T. Jue, C. Malloy, J. M. Park. Hyperpolarized 13C MRI detects in-vivo effect of exercise on pyruvate metabolism in human skeletal muscle. International Society of Magnetic Resonance in Medicine,Virtual Conference. May 2021. #678Oral presentationSumma cum laude award.
  3. J. Ma, C. Harrison, J. Ratnakar, G. Reed, R. Schulte, V. Zaha, C. Malloy, J. M. Park. In vivo T2* of hyperpolarized 13C-metabolites in human brain, heart, kidney and spleen: an imaging approach. International Society of Magnetic Resonance in Medicine, Virtual Conference. May 2021. #3585
  4. J. Ma, C. Malloy, C. Harrison, J. Ratnakar, G. Reed, V. Zaha, J. M. Park. Dual-phase imaging of cardiac metabolism using hyperpolarized [1-13C]pyruvate. International Society of Magnetic Resonance in Medicine, Virtual Conference. May 2021. #3577Magna cum laude award.
  5. J. Alger, J. M. Park, J. Ma, M. Roy, C. Harrison, J. Ratnakar, A. Chen, G. Reed, A. D. Sherry, V. Zaha, C. Malloy. Pyruvate infusion rates for hyperpolarized metabolite imaging of human heart. International Society of Magnetic Resonance in Medicine, Virtual Conference. May 2021. #1832.
  6. J. M. Park, G. Reed, J. Liticker, W. Putnam, A. Chandra, K. Yaros, A. Afzal, J. MacNamara, R. Hall, C. Harrison, A. Muthukumar, C. Ayers, J. de Lemos, C. Malloy, H.-C. Li, B. Haley, V. Zaha. Effect of doxorubicin treatment on myocardial metabolism in patients with breast cancer. International Society of Magnetic Resonance in Medicine, Virtual Conference. May 2021. #22. Oral presentation.
  7. J. Ma, J. M. Park. Super-resolution hyperpolarized 13C imaging of human brain using patch-based algorithm. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #3021.
  8. J. Chen, E. LaGue, J. Li, E. Hackett, I. Corbin, K. Billingsley, J. M. Park. Hyperpolarized [1-13C]glycerate as probe to assess glycolytic activity in a rat model of hepatocellular carcinoma. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #691. Oral presentationMagna cum laude award.
  9. J. Chen, E. Hackett, J. M. Park. Hyperpolarized [1- 13C] lactate as an agent for measuring pyruvate carboxylase activity. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #3001.
  10. J. Chen, T. Patel, C. Harrison, G. Reed, C. Malloy, B. Mickey, J. M. Park. Hyperpolarized 13C pyruvate imaging of glioblastoma patients. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #632. Power pitch.
  11. J. Chen, R. Martin, L. Lumata, Z. Kovács, J. M. Park. Feasibility of hyperpolarized [89Y]-labeled substrates for in vivo studies. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #3024. Best presentation award (1st place) in Hyperpolarization Methods & Equipment Study Section.
  12. E. Hackett, M. Pinho, C. Harrison, G. Reed, S. Barshikar, C. Madden, J. M. Park. Imaging acute metabolic changes in mild traumatic brain injury patients using hyperpolarized [1-13C] pyruvate. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #697. Oral presentation.
  13. J. Ma, E, Hackett, J. M. Park. In vivo T* mapping of hyperpolarized 13C-labeled metabolites using a metabolite-selective multi-echo spiral imaging sequence. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #3051.
  14. J. M. Park, E. Hackett, C. Harrison, G. Reed, A. Chhabra, C. Malloy. Effects of anaerobic exercise in skeletal muscle measured by hyperpolarized [1-13C]pyruvate in humans. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #3000.
  15. G. Reed, J. M. Park, J. Ma, C. Harrison, R. Schulte, A. Chen, S. Pena, J. Baxter, K. Derner, M. Tai, A. D. Sherry, V. Zaha, C. Malloy. RF coil and gradient shim considerations for hyperpolarized 13C imaging of the human myocardium. International Society of Magnetic Resonance in Medicine, Virtual Conference. August 2020. #2240.
  16. K. Yaros, J. M. Park, C. Malloy, J. Algers, T. Hussain, V. Zaha, Mathematical modeling of hyperpolarized pyruvate metabolism measurement in human heart. American Heart Association - Basic Cardiovascular Sciences Scientific Sessions, July 2020. #535.
  17. J. Singh, E. H. Suh, A. D. Sherry, C. Malloy, J. M. Park, Z. Kovács. Hyperpolarized, 13C-labeled 2-ketoglutarate derivatives as metabolic MR probes for the citric acid cycle. Contrast Media Research Symposium, Sicily, Italy. November 2019. #40.
  18. J. Chen, E. Hackett, R. Martin, Z. Kovacs, J. M. Park. Hyperpolarized [1-13C] alanine ethyl ester for assessment of hepatic alanine metabolism. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #719. Oral presentationMagna cum laude award.
  19. E. Hackett, B. Cheng, D. Spielman, K. Billingsley, R. Chopra, J. M. Park. Effect of opening the blood-brain barrier with focused ultrasound on 13C hyperpolarized imaging in rat brain. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #4313.
  20. J. Ma, E. Hackett, R. Schulte, J. M. Park. Simultaneous assessment of hyperpolarized [1-13C]lactate and [13C]bicarbonate with fly-back echo planar imaging. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #1949.
  21. J. Ma, R. Hashoian, C. Sun, S. Wright, A. Ivanishev, R. Lenkinski, C. Malloy, A. Chen, J. M. Park. Development of 1H/13C RF head coil for hyperpolarized 13C imaging of human brain. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #568. Power pitchMagna cum laude award.
  22. J. M. Park, J. Liticker, C. Harrison, G. Reed, T. Hever, J. Ma, R. Martin, D. Mayer, R. Hashoian, C. Madden, M. Pinho, C. Malloy. Feasibility and reproducibility of imaging brain metabolism using hyperpolarized 13C pyruvate in humans. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #4311.
  23. J. M. Park, R. Hashoian, G. Reed, A. Chen, C. Malloy. Quadrature transmit and receive array 13C RF coil for clinical cardiac and hepatic imaging with hyperpolarized 13C-substrates. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #4293.
  24. G. Reed, R. Schulte, J. M. Park, C. Malloy, R. Hansen, A. Chen. Protocol for multi-site quantitative evaluation of 13C radio frequency coils. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2019. #2510.
  25. E. H. Suh, E. Hackett, D. Sherry, J. M. Park. In vivo hyperpolarized 13C imaging of increased oxidation of branched-chain amino acid in F98 rat glioma. World Molecular Imaging Congress, Seattle, Washington. November 2018. #P351.
  26. E. Hackett, J. Chen, L. Ingle, B. Bartnik-Olson, J. M. Park. Longitudinal changes in pyruvate metabolism in the brain after traumatic injury. Joint Symposium of the International and National Neurotrauma Societies and AANS/CNS Section on Neurotrauma and Critical Care, Toronto, Canada. August 2018. #657.
  27. J. M. Park, M. Wu, J. Chen, T. Hever, X. Wen, J. Alger, D. Spielman, K. Billingsley. Hyperpolarized sodium [1- 13C]glycerate as a probe for assessing glycolysis in vivo. International Society of Magnetic Resonance In Medicine, Paris, France. June 2018. #274. Oral presentation
  28. J. M. Park, S. Stender, C. Malloy, J. Cohen, R. DeBerardinis, V. Zaha. Rapid hepatic glycogen synthesis in humans using dynamic 13CMRspectroscopy. International Society of Magnetic Resonance In Medicine, Paris, France. June 2018. #4484.
  29. S. Cheshkov, E. Hackett, R. Martin, S. Ganji, I. Dimitrov, J. M. Park. Toward investigating cerebral metabolism using hyperpolarized pyruvate on a human 7T system. International Society of Magnetic Resonance In Medicine, Paris, France. June 2018. #3697.
  30. E. Hackett, L. Ingle, B. Bartnik-Olson, J. M. Park. Assessment of metabolic changes in traumatic brain injury using hyperpolarized [1- 13C]pyruvate: a longitudinal study. International Society of Magnetic Resonance In Medicine, Paris, France. June 2018. #4960.
  31. M. Lauritzen, M. Merchant, T. Jang, K. Datta, R. Hurd, S. Liu, J. M. Park, L. Recht, D. Spielman. Metabolic interactions of simultaneous 18F-FDG PET and hyperpolarized 13C MRI. International Society of Magnetic Resonance In Medicine, Paris, France. June 2018. #3691.
  32. J. M. Park, R. Hurd, D. Spielman. Optimization of redox-state assessment in rat liver using hyperpolarized [1-13C]alanine. International Society of Magnetic Resonance In Medicine, Honolulu, HI. May 2017. #3611.
  33. E. H. Suh,W. Ou, I. Corbin, D. Sherry, J. M. Park. Imaging branched-chain amino acid metabolism in glioma using hyperpolarized [1-13C]a-ketoisocaproate. International Society of Magnetic Resonance In Medicine, Honolulu, HI. May 2017. #3604.
  34. K. Valluru, J. M. Park, S. Bachawal, C. Liu, V. Taviani, P. Gulaka, Y. Saenz, S. Felt, J. Vilches-Moure, Z. Cheng, D. Spielman, J. Willmann. Hyperpolarized MRS/PET/ultrasound molecular image fusion for improved diagnosis and guided biopsy of prostate cancer. Radiological Society of North America, Chicago, IL. November 2016. #GU212-SD-MOA3
  35. K. Valluru, J. M. Park, S. Bachawal, C. Liu, S. Felt, J. Vilches-Moure, Z. Cheng, D. Spielman, J. Willmann. Real-time fused hyperpolarized MRS/PET/ultrasound molecular imaging for improved diagnosis of prostate cancer. World Molecular Imaging Congress, New York, NY. September 2016.
  36. J. M. Park, S.-C. Liu, M. Merchant, T. Jang, K. Datta, P. Gulaka, Z. Corbin, R. Hurd, L. Recht, D. Spielman. Initial experiences of simultaneous in vivo metabolic imaging using MRI, PET, and hyperpolarized 13C MRSI from rat glioma models. International Society of Magnetic Resonance In Medicine, Singapore. May 2016. #674. Oral presentation.
  37. J. M. Park, S. Josan, D. Mayer, R. Hurd, Y. Chung, D. Bendahan, D. Spielman, T. Jue. Observation of in vivo lactate metabolism in skeletal muscle using hyperpolarized 13C MRS. International Society of Magnetic Resonance In Medicine, Singapore. May 2016. #2265. Magna cum laude award.
  38. J. M. Park, R. Hurd, S.-C. Liu, D. Spielman. Noninvasive in vivo assessment of cytosolic redoxstate in rat liver using hyperpolarized [1-13C]alanine. International Society of Magnetic Resonance In Medicine, Singapore. May 2016. #3672.
  39. J. M. Park, R. Hurd, D. Mayer, L. Recht, D. Spielman. Assessing microenvironment in rat glioma model using hyperpolarized 13C MRSI with a sliding window. International Society of Magnetic Resonance In Medicine, Toronto, Canada. May 2015. #4610.
  40. S. Holdsworth, T. Christen, K. Yeom, J. M. Park, G. Zaharchuk, M. Moseley. Ferumoxytol-enhanced plural contrast imaging of the human brain. International Society of Magnetic Resonance In Medicine, Toronto, Canada. May 2015. #1716.
  41. A.Wibowo, J. M. Park, R. Hurd, G. Sommer, C. Khosla, D. Spielman. Development of hyperpolarized 13C-MRS probes for oxidative stress measurement. International Society of Magnetic Resonance In Medicine, Toronto, Canada. May 2015. #1886.
  42. J. M. Park, S. Josan, R. Hurd, J. Graham, P. Havel, D. Bendahan, D. Mayer, D. Spielman, T. Jue. Mitochondrial metabolism of diabetic skeletal muscle measured by hyperpolarized 13C MR spectroscopy. American Diabetes Association Scientific Sessions, San Francisco, CA. June 2014. #244-LB.
  43. J. M. Park, M. Khalighi, D. Qiu, G. Zaharchuk, C. Liu, M. Moseley. Considerations in p-space susceptibility tensor imaging: k-space truncation effect, T2* dependence, and 3T/7T comparison. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #3253.
  44. J. M. Park, S. Josan, T. Jang, M. Merchant, R. Hurd, L. Recht, D. Spielman. Metabolic changes in a rat glioma model after anti-angiogenic treatment measured by MR spectroscopic imaging of hyperpolarized [1-13C]pyruvate. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #846. Oral presentationSumma cum laude award.
  45. J. M. Park, S. Josan, D. Mayer, R. Hurd, D. Bendahan, D. Spielman, T. Jue. Skeletal muscle metabolism measured by hyperpolarized 13C MR spectroscopy. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #827. Oral presentationSumma cum laude award.
  46. J. M. Park, S.-S. Tee, R. Hurd, K. Brimacombe, M. Boxer, D. Mayer, B. Rutt, D. Spielman. Effect of PKM2 activator and 2-deoxyglucose treatments on cancer metabolism measured in vivo by hyperpolarized 13C MR spectroscopic imaging. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #4044.
  47. J. M. Park, S. Josan, R. Hurd, J. Graham, P. Havel, D. Bendahan, D. Mayer, D. Spielman, T. Jue. Assessment of diabetic skeletal muscle metabolism using hyperpolarized 13C MR spectroscopy. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #1007. Oral presentationSumma cum laude award.
  48. S. Josan, J. M. Park, R. Hurd, D. Spielman, D. Mayer. Improved dynamic 3D spiral CSI with interleaved spectral band excitation for metabolic imaging of hyperpolarized [2-13C]pyruvate. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #3802.
  49. S. Josan, K. Billingsley, J. Orduna, J. M. Park, R. Luong, S. Reddy, R. Hurd, A. Pfefferbaum, D. Spielman, D.Mayer. Assessment of acute inflammatory liver injury in a rat CCl4 model using metabolic imaging of hyperpolarized [1-13C]pyruvate. International Society of Magnetic Resonance In Medicine, Milan, Italy. May 2014. #3797.
  50. J. M. Park, T. Jang, S. Josan, D. Mayer, D. Spielman, L. Recht. The Bevacizumab pseudoresponse: disappointment or opportunity? Quadrennial Meeting of the World Federation of Neuro-Oncology in conjunction with Annual Meeting of the Society for Neuro-Oncology, San Francisco, CA. November 2013.
  51. S.-S. Tee, J. M. Park, K. Billingsley, B. Rutt, D. Spielman. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxyglucose. International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA. October 2013.
  52. J. M. Park, S. Josan, D. Mayer, R. Hurd, D. Spielman, D. Bendahan, T. Jue. Direct observation of lactate metabolism in skeletal muscle with hyperpolarized 13C-NMR. World Molecular Imaging Congress, Savannah, GA. September 2013. Oral presentation.
  53. J. M. Park, S. Josan, D. Mayer, R. Hurd, D. Spielman, J. Graham, P. Havel, D. Bendahan, T. Jue. Reduced oxidative metabolism in T2DM diabetic skeletal muscle as observed by hyperpolarized 13C-NMR. World Molecular Imaging Congress, Savannah, GA. September 2013. #LBAP80.
  54. J. M. Park, S. Josan, T. Jang, M. Merchant, R. Hurd, D. Mayer, D. Spielman, L. Recht. Response of C6 glioma to anti-angiogenesis treatment measured by metabolic imaging of hyperpolarized [1-13C]pyruvate. Annual World Molecular Imaging Congress, Savannah, GA. September 2013. #LBAP95.
  55. S.-S. Tee, J. M. Park, K. Billingsley, M. Brimacombe, M. Boxer, B. Rutt, D. Spielman. Detection of PKM2 activator treatment in tumor cells using hyperpolarized magnetic resonance spectroscopy. World Molecular Imaging Congress, Savannah, GA. September 2013. #P495. Best poster award.
  56. J. M. Park, R. Hurd, K. Billingsley, S. Josan, Y.-F. Yen, D. Mayer, D. Spielman. Differentiation of pyruvate flux versus exchange in rat liver in vivo using a three-site exchange model. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #655. Oral presentationSumma cum laude award.
  57. J. M. Park, S. Josan, T. Jang, M. Merchant, R. Watkins, Y.-F. Yen, R. Hurd, L. Recht, D. Spielman, D. Mayer. Fast 3D spiral chemical shift imaging of mitochondrial metabolism in brain with C6 glioma using hyperpolarized [2-13C]pyruvate. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013 #3938.
  58. J. M. Park, Y.-F. Yen, P. Balchandani, S. Josan, R. Hurd, D. Mayer, D. Spielman. Spectrally interleaved multi-echo sequence for measurement of hyperpolarized [1-13C]pyruvate metabolism. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #3944
  59. S. Josan, J. M. Park, Y.-F. Yen, R. Hurd, A. Pfefferbaum, D. Spielman, D. Mayer. Investigation of substrate dose on rat cardiac metabolism in vivo using MRS of hyperpolarized [2- 13C]pyruvate. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #3911.
  60. D. Qiu, T. Christen, J. M. Park, M. Moseley, G. Zaharchuk. Resting state fMRI using multi echo EPI (ME-EPI): a study of echo time dependence of sensitivity. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #2239.
  61. K. Billingsley, S. Josan, J. M. Park, S.-S. Tee, Y.-F. Yen, R. Hurd, D. Mayer, D. Spielman. Hyperpolarized [1,4-13C]-diethylsuccinate: a DNP substrate for in vivo metabolic imaging. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #3935.
  62. K. Billingsley, S. Josan, J. M. Park, Y.-F. Yen, R. Hurd, D. Mayer, D. Spielman. Branched-chain amino acid metabolism in prostate cancer: hyperpolarized [1-13C]-ketoisocaproate as a novel molecular probe. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #3933.
  63. R. Hurd, S. Josan, J. M. Park, Y.-F. Yen, D. Mayer, D. Spielman. Optimized sampling of metabolically labeled [2-13C]lactate following injection of hyperpolarized [2-13C]pyruvate. International Society of Magnetic Resonance In Medicine, Salt Lake City, Utah. April 2013. #3917.
  64. S. Josan, K. Billingsley, L. Senadheera, J. M. Park, Y.-F. Yen, R. Hurd, A. Pfefferbaum, D. Spielman, D. Mayer. Effects of isoflurane anesthesia on hyperpolarized 13C metabolic measurements in rat brain. World Molecular Imaging Congress, Dublin, Ireland. September 2012. #P476.
  65. J. M. Park, L. Recht, S. Josan, T. Jang, M. Merchant, Y.-F. Yen, R. Hurd, D. Spielman, D. Mayer. Metabolic response of glioma to dichloroacetate measured by hyperpolarized 13C MR spectroscopic imaging. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4312.
  66. J. M. Park, S. Josan, Y.-F. Yen, R. Hurd, D. Spielman, D. Mayer. Assessment of dichloroacetate effect on TCA cycle in rat brain using MR spectroscopic imaging of hyperpolarized [2- 13C]pyruvate. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4323.
  67. J. M. Park, R. Hurd, S. Josan, Y.-F. Yen, D. Mayer, D. Spielman. Differentiation of flux and isotopic exchange using co-polarization of [2-13C]pyruvate and [1-13C]lactate. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4298.
  68. S. Josan, J. M. Park, Y.-F. Yen, R. Hurd, A. Pfefferbaum, D. Spielman, D. Mayer. In vivo investigation of DCA-modulated cardiac metabolism in the rat using hyperpolarized 13C MRS. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4322.
  69. L. Senadheera, D. Mayer, S. Josan, Y.-F. Yen, M. Darpolor, J. M. Park, R. Hurd, R. Luong, L. Xing, D. Spielman. Detection of radiation response of prostate cancer in TRAMP with hyperpolarized 13C MR spectroscopic imaging. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #1682. 
  70. Y.-F. Yen, S. Josan, L. Senadheera, J. M. Park, A. Takahashi, L. Recht, T. Jang, M. Merchant, P. Balchandani, D. Mayer, J. Tropp, L. Xing, D. Spielman, A. Pfefferbaum, R. Hurd, P. Le Roux. Non-CPMG echo-train sequence for T2 mapping and large SNR gain in hyperpolarized 13C application. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4295.
  71. R. Hurd, D. Spielman, S. Josan, J. M. Park, Y.-F. Yen, A. Pfefferbaum, D. Mayer. Quantitative measurement of pyruvate-lactate exchange rate in both directions using exchange-linked dissolution agents (ELDA) in hyperpolarized 13C metabolic imaging. International Society of Magnetic Resonance In Medicine, Melbourne, Australia. May 2012. #4304.
  72. J. M. Park, S. Josan, T. Jang, M. Merchant, Y.-F. Yen, R. Hurd, L. Recht, D. Spielman, D. Mayer. Metabolic kinetics of a glioma model using hyperpolarized 13C magnetic resonance spectroscopic imaging. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2011. #3517.
  73. D. Mayer, Y.-F. Yen, R. Hurd, S. Josan, J. M. Park, A. Pfefferbaum, D. Spielman. Hyperpolarized [1-13C]-lactate as a tool for the in vivo investigation of cardiac metabolism. International Society of Magnetic Resonance In Medicine, Montreal, Canada. May 2011. #1505.